| Gene Symbol |
CBL
|
| Entrez Gene |
867
|
| Alt Symbol |
C-CBL, CBL2, FRA11B, NSLL, RNF55
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
Cbl proto-oncogene, E3 ubiquitin protein ligase
|
| Other Description |
Cas-Br-M (murine) ecotropic retroviral transforming sequence|E3 ubiquitin-protein ligase CBL|RING finger protein 55|casitas B-lineage lymphoma proto-oncogene|fragile site, folic acid type, rare, fra(11)(q23.3)|oncogene CBL2|proto-oncogene c-Cbl|signal transduction protein CBL
|
| Swissprots |
P22681 A3KMP8
|
| Accessions |
CAA57977 EAW67476 P22681 AA806454 AK092300 AL832396 BC132733 AAI32734 BC136463 AAI36464 BG722940 BX648139 DB457271 X57110 CAA40393 X69207 XM_011543057 XP_011541359 NM_005188 NP_005179
|
| Function |
Adapter protein that functions as a negative regulator of many signaling pathways that are triggered by activation of cell surface receptors. Acts as an E3 ubiquitin-protein ligase, which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their degradation by the proteasome. Recognizes activated receptor tyrosine kinases, including KIT, FLT1, FGFR1, FGFR2, PDGFRA, PDGFRB, EGFR, CSF1R, EPHA8 and KDR and terminates signaling. Recognizes membrane-bound HCK, SRC and other kinases of the SRC family and mediates their ubiquitination and degradation. Participates in signal transduction in hematopoietic cells. Plays an important role in the regulation of osteoblast differentiation and apoptosis. Essential for osteoclastic bone resorption. The 'Tyr-731' phosphorylated form induces the activation and recruitment of phosphatidylinositol 3-kinase to the cell membrane in a signaling pathway that is critical for osteoclast function. May be
|
| Subcellular Location |
Cytoplasm. Cell membrane. Note=Colocalizes with FGFR2 in lipid rafts at the cell membrane.
|
| Top Pathways |
Proteoglycans in cancer, Ubiquitin mediated proteolysis, Bacterial invasion of epithelial cells, Endocytosis, ErbB signaling pathway
|