Gene Symbol | LETM1 |
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Entrez Gene | 3954 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | leucine zipper-EF-hand containing transmembrane protein 1 |
Other Description | LETM1 and EF-hand domain-containing protein 1, mitochondrial|Mdm38 homolog |
Swissprots | Q9UF65 B4DED2 O95202 |
Accessions | EAW82560 EAW82561 O95202 AF061025 AAD13138 AK293572 BAG57043 AK310563 AL133650 CAB63769 BC014500 AAH14500 BC021208 AAH21208 DQ893606 ABM84532 XM_005247970 XP_005248027 XM_006713884 XP_006713947 NM_012318 NP_036450 |
Function | Crucial for the maintenance of mitochondrial tubular networks and for the assembly of the supercomplexes of the respiratory chain. Required for the maintenance of the tubular shape and cristae organization. {ECO:0000269|PubMed:18628306}. |
Subcellular Location | Mitochondrion inner membrane {ECO:0000269|PubMed:14706454, ECO:0000269|PubMed:15138253, ECO:0000269|PubMed:18628306}; Single-pass membrane protein {ECO:0000269|PubMed:14706454, ECO:0000269|PubMed:15138253, ECO:0000269|PubMed:18628306}. |
LETM1 CRISPR/Cas9 KO Plasmid (h) - sc-406163 from Santa Cruz Biotechnology
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LETM1 HDR Plasmid (h) - sc-406163-HDR from Santa Cruz Biotechnology
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LETM1 Double Nickase Plasmid (h) - sc-406163-NIC from Santa Cruz Biotechnology
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LETM1 Double Nickase Plasmid (h2) - sc-406163-NIC-2 from Santa Cruz Biotechnology
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LETM1 CRISPR Activation Plasmid (h) - sc-406163-ACT from Santa Cruz Biotechnology
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LETM1 CRISPR Activation Plasmid (h2) - sc-406163-ACT-2 from Santa Cruz Biotechnology
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LETM1 Lentiviral Activation Particles (h) - sc-406163-LAC from Santa Cruz Biotechnology
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LETM1 Lentiviral Activation Particles (h2) - sc-406163-LAC-2 from Santa Cruz Biotechnology
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LETM1 siRNA (h) - sc-89079 from Santa Cruz Biotechnology
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LETM1 shRNA Plasmid (h) - sc-89079-SH from Santa Cruz Biotechnology
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LETM1 shRNA (h) Lentiviral Particles - sc-89079-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU063211 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN11655 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND11655 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09266 from Sigma-Aldrich
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LETM1 siRNA (Human) - CRH2677 from Cohesion Biosciences
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LETM1 RNAi - H00003954-R01 from Novus Biologicals
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LETM1 CRISPR/Cas9 KO Plasmid (h2) - sc-406163-KO-2 from Santa Cruz Biotechnology
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LETM1 HDR Plasmid (h2) - sc-406163-HDR-2 from Santa Cruz Biotechnology
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shRNA set against Human LETM1 (NM_012318.2) - SHH329699 from Creative biogene
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LETM1 shRNA Plasmid (Human) - CHH2677 from Cohesion Biosciences
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