Gene Symbol | FOXD3 |
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Entrez Gene | 27022 |
Alt Symbol | AIS1, Genesis, HFH2, VAMAS2 |
Species | Human |
Gene Type | protein-coding |
Description | forkhead box D3 |
Other Description | HNF3/FH transcription factor genesis|forkhead box protein D3 |
Swissprots | Q9UDD1 Q9UJU5 Q9BYM2 |
Accessions | AAF05844 EAX06575 Q9UJU5 AF086235 BC172266 AAI72266 BC172572 AAI72572 L12142 AAK13574 NM_012183 NP_036315 |
Function | Binds to the consensus sequence 5'-A[AT]T[AG]TTTGTTT-3' and acts as a transcriptional repressor. Also acts as a transcriptional activator. Promotes development of neural crest cells from neural tube progenitors. Restricts neural progenitor cells to the neural crest lineage while suppressing interneuron differentiation. Required for maintenance of pluripotent cells in the pre-implantation and peri-implantation stages of embryogenesis. {ECO:0000269|PubMed:11891324}. |
Subcellular Location | Nucleus {ECO:0000305}. |
Tissue Specificity | Expressed in chronic myeloid leukemia, Jurkat T-cell leukemia and teratocarcinoma cell lines, but not in any other cell lines or normal tissues examined. {ECO:0000269|PubMed:8499623}. |
FOXD3 CRISPR/Cas9 KO Plasmid (h) - sc-402673 from Santa Cruz Biotechnology
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FOXD3 HDR Plasmid (h) - sc-402673-HDR from Santa Cruz Biotechnology
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FOXD3 Double Nickase Plasmid (h) - sc-402673-NIC from Santa Cruz Biotechnology
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FOXD3 Double Nickase Plasmid (h2) - sc-402673-NIC-2 from Santa Cruz Biotechnology
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FOXD3 CRISPR Activation Plasmid (h) - sc-402673-ACT from Santa Cruz Biotechnology
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FOXD3 CRISPR Activation Plasmid (h2) - sc-402673-ACT-2 from Santa Cruz Biotechnology
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FOXD3 Lentiviral Activation Particles (h) - sc-402673-LAC from Santa Cruz Biotechnology
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FOXD3 Lentiviral Activation Particles (h2) - sc-402673-LAC-2 from Santa Cruz Biotechnology
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FOXD3 siRNA (h) - sc-43768 from Santa Cruz Biotechnology
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FOXD3 shRNA Plasmid (h) - sc-43768-SH from Santa Cruz Biotechnology
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FOXD3 shRNA (h) Lentiviral Particles - sc-43768-V from Santa Cruz Biotechnology
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FoxD3 RNAi - H00027022-R01 from Novus Biologicals
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CompoZr® Knockout ZFN Kit - CKOZFN8883 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8883 from Sigma-Aldrich
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FOXD3 siRNA (Human) - CRH8926 from Cohesion Biosciences
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FOXD3 - MBS8221475 from MyBioSource
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shRNA set against Human FOXD3 (NM_012183.2) - SHH296465 from Creative biogene
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shRNA set against Human FOXD3(NM_012183.2) - SHH066071 from Creative biogene
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Human FOXD3 siRNA - orb269428 from Biorbyt
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FOXD3 shRNA Plasmid (Human) - CHH8926 from Cohesion Biosciences
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FOXD3 miRNA 3'UTR clone - MiUTR1H-03815 from Creative biogene
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