Gene Symbol | Dmrt2 |
---|---|
Entrez Gene | 226049 |
Alt Symbol | Terra |
Species | Mouse |
Gene Type | protein-coding |
Description | doublesex and mab-3 related transcription factor 2 |
Other Description | dmrt2|doublesex- and mab-3-related transcription factor 2|doublesex-like 2 protein|terra homolog |
Swissprots | Q9WVM0 Q9JJU0 Q3USI4 Q3USI7 Q9JJU3 Q8K185 Q8BG36 |
Accessions | CAB93343 CAB93344 CAB93345 CAB93346 EDL41636 Q8BG36 AF080623 AAD38425 AF539811 AAN77205 AK044891 BAC32130 AK140337 BAE24344 AK140347 BAE24347 BC027669 AAH27669 XM_006526982 XP_006527045 XM_006526983 XP_006527046 NM_145831 NP_665830 |
Function | Transcriptional activator that directly regulates early activation of the myogenic determination gene MYF5 by binding in a sequence-specific manner to the early epaxial enhancer element of it. Involved in somitogenesis during embryogenesis and somite development and differentiation into sclerotome and dermomyotome. Required for the initiation and/or maintenance of proper organization of the sclerotome, dermomyotome and myotome. Is not required for sex determination and/or differentiation in embryonic development. Also not involved in symmetric somite formation and hence does not regulate the laterality pathway that controls left- right asymmetric organ positioning. {ECO:0000269|PubMed:10021344, ECO:0000269|PubMed:16387292, ECO:0000269|PubMed:17605809, ECO:0000269|PubMed:20368965, ECO:0000269|PubMed:21203428}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00070, ECO:0000269|PubMed:17605809}. |
Tissue Specificity | Expressed in testis. {ECO:0000269|PubMed:12609607, ECO:0000269|PubMed:20368965}. |
DMRT2 CRISPR/Cas9 KO Plasmid (m) - sc-432587 from Santa Cruz Biotechnology
|
||||||||
DMRT2 HDR Plasmid (m) - sc-432587-HDR from Santa Cruz Biotechnology
|
||||||||
DMRT2 Double Nickase Plasmid (m) - sc-432587-NIC from Santa Cruz Biotechnology
|
||||||||
DMRT2 Double Nickase Plasmid (m2) - sc-432587-NIC-2 from Santa Cruz Biotechnology
|
||||||||
DMRT2 CRISPR Activation Plasmid (m) - sc-432587-ACT from Santa Cruz Biotechnology
|
||||||||
DMRT2 CRISPR Activation Plasmid (m2) - sc-432587-ACT-2 from Santa Cruz Biotechnology
|
||||||||
DMRT2 Lentiviral Activation Particles (m) - sc-432587-LAC from Santa Cruz Biotechnology
|
||||||||
DMRT2 Lentiviral Activation Particles (m2) - sc-432587-LAC-2 from Santa Cruz Biotechnology
|
||||||||
DMRT2 siRNA (m) - sc-77158 from Santa Cruz Biotechnology
|
||||||||
DMRT2 shRNA Plasmid (m) - sc-77158-SH from Santa Cruz Biotechnology
|
||||||||
DMRT2 shRNA (m) Lentiviral Particles - sc-77158-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU003671 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN30057 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND30057 from Sigma-Aldrich
|
||||||||
DMRT2 siRNA (Mouse) - CRN2479 from Cohesion Biosciences
|
||||||||
DMRT2 - MBS8211108 from MyBioSource
|
||||||||
shRNA set against Mouse DMRT2 (NM_145831.3) - SHH278873 from Creative biogene
|
||||||||
shRNA set against Mouse Dmrt2(NM_145831.3) - SHH008507 from Creative biogene
|
||||||||
DMRT2 shRNA Plasmid (Mouse) - CHN2479 from Cohesion Biosciences
|
||||||||
DMRT2 miRNA 3'UTR clone - MiUTR1M-03901 from Creative biogene
|