| Gene Symbol |
MLST8
|
| Entrez Gene |
64223
|
| Alt Symbol |
GBL, GbetaL, LST8, POP3, WAT1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
MTOR associated protein, LST8 homolog (S. cerevisiae)
|
| Other Description |
TORC subunit LST8|gable|mammalian lethal with SEC13 protein 8|protein GbetaL|target of rapamycin complex subunit LST8
|
| Swissprots |
D3DU88 Q9HA66 Q5M800 B3KMM4 Q9BVC4 Q8WUI5 Q86Y18 Q9UJV6 B4DY00
|
| Accessions |
EAW85537 EAW85538 EAW85539 EAW85540 EAW85541 EAW85542 Q9BVC4 AF195883 AAF04308 AI933692 AK021536 BAG51036 AK022227 BAB13990 AK098762 AK123195 AK302201 BAG63562 AK304390 BAG65225 AU117583 AU121635 AY223837 AAO73410 BC001313 AAH01313 BC017119 AAH17119 BC020499 BC052292 AAH52292 BC088354 AAH88354 BI761765 BQ014640 DA382215 DQ891611 ABM82537 DQ894803 ABM85729 EU176591 ABW03392 XM_005255475 XP_005255532 XM_005255478 XP_005255535 XM_005255479 XP_005255536 XR_243294 XR_243296 NM_001199173 NP_001186102 NM_001199174 NP_001186103 NM_001199175 NP_001186104 NM_022372 NP_071767
|
| Function |
Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. I
|
| Subcellular Location |
Cytoplasm {ECO:0000250}.
|
| Tissue Specificity |
Broadly expressed, with highest levels in skeletal muscle, heart and kidney. {ECO:0000269|PubMed:12408816}.
|
| Top Pathways |
PI3K-Akt signaling pathway, mTOR signaling pathway
|
