MLST8

Gene Symbol	MLST8
Entrez Gene	64223
Alt Symbol	GBL, GbetaL, LST8, POP3, WAT1
Species	Human
Gene Type	protein-coding
Description	MTOR associated protein, LST8 homolog (S. cerevisiae)
Other Description	TORC subunit LST8|gable|mammalian lethal with SEC13 protein 8|protein GbetaL|target of rapamycin complex subunit LST8
Swissprots	D3DU88 Q9HA66 Q5M800 B3KMM4 Q9BVC4 Q8WUI5 Q86Y18 Q9UJV6 B4DY00
Accessions	EAW85537 EAW85538 EAW85539 EAW85540 EAW85541 EAW85542 Q9BVC4 AF195883 AAF04308 AI933692 AK021536 BAG51036 AK022227 BAB13990 AK098762 AK123195 AK302201 BAG63562 AK304390 BAG65225 AU117583 AU121635 AY223837 AAO73410 BC001313 AAH01313 BC017119 AAH17119 BC020499 BC052292 AAH52292 BC088354 AAH88354 BI761765 BQ014640 DA382215 DQ891611 ABM82537 DQ894803 ABM85729 EU176591 ABW03392 XM_005255475 XP_005255532 XM_005255478 XP_005255535 XM_005255479 XP_005255536 XR_243294 XR_243296 NM_001199173 NP_001186102 NM_001199174 NP_001186103 NM_001199175 NP_001186104 NM_022372 NP_071767
Function	Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1- mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. I
Subcellular Location	Cytoplasm {ECO:0000250}.
Tissue Specificity	Broadly expressed, with highest levels in skeletal muscle, heart and kidney. {ECO:0000269|PubMed:12408816}.
Top Pathways	PI3K-Akt signaling pathway, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human G protein beta subunit like peptide - ab39766 from Abcam Category Peptide Species Human

MLST8 / GBL Antibody Blocking Peptide - LS-E6480 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MLST8 / GBL Antibody Blocking Peptide - LS-E30135 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

MLST8 / GBL Antibody Blocking Peptide - LS-E21042 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

MLST8 / GBL Antibody Blocking Peptide - LS-E9564 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human GBL Protein - H00064223-P01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

GBL Blocking Peptide - NBP1-77213PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

GBL Peptide - P3233 from Novus Biologicals Category Peptide Species Human

GBL-Antibody-C-term-Blocking-Peptide - BP19234b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GBL-Antibody-Center-Blocking-Peptide - BP8200c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

mLST8 / GBL Protein - GTX108631-pro from GeneTex Category Protein Prices $299.00 Sizes 10 μg Source E. coli Species Human

GBL Blocking Peptide - 33R-1639 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

Human GbL Protein - abx066709 from Abbexa Category Protein Source E.coli Species Human

LST8 / GBL - H00064223-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

LST8 / GBL - H00064223-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

LST8 / GBL Control Peptide - AP30359CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

G Protein Beta Subunit Like Protein (GbL), Human - 20-9547 from ARP American Research Products Category Protein Prices $519.00 Sizes 50 µg Source E.coli Species Human

GbL Peptide - 3495P from ProSci Category Peptide Species Human

MLST8 fusion protein - Ag2359 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human MTOR Associated Protein, LST8 Homolog (S. cerevisiae), T7-tagged - MLST8-2917H from Creative Biomart Category Protein

Recombinant Human MLST8, T7 -tagged - MLST8-26546TH from Creative Biomart Category Protein Source E. coli

Recombinant G Protein Beta Subunit Like Protein (GbL) - RPN253Hu01 from Uscn Life Science Inc. Category Protein Source E.coli Species Human

Recombinant G Protein Beta Subunit Like Protein (GbL) - RPN253Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Target of rapamycin complex subunit LST8(MLST8) - CSB-YP863130HU CSB-EP863130HU CSB-BP863130HU CSB-MP863130HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Target of rapamycin complex subunit LST8 (MLST8), Recombinant Protein - MBS1342722 from MyBioSource Category Protein Prices $1,085.00, $1,085.00, $1,315.00, $1,315.00, $1,710.00, $1,710.00, $2,170.00, $2,170.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

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