Gene Symbol | CCDC67 |
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Entrez Gene | 159989 |
Alt Symbol | - |
Species | Human |
Gene Type | protein-coding |
Description | coiled-coil domain containing 67 |
Other Description | coiled-coil domain-containing protein 67|deuterosome protein 1 |
Swissprots | Q8NEF1 Q05D60 Q96LL7 |
Accessions | EAW66898 EAW66899 EAW66900 Q05D60 AK058122 BAB71673 AK127973 BAC87213 BC017929 AAH17929 BC031247 AAH31247 BC050325 DB449834 XM_005273802 XP_005273859 XM_011542629 XP_011540931 XM_011542630 XP_011540932 XM_011542631 XP_011540933 XM_011542632 XP_011540934 XM_011542633 XP_011540935 XM_011542634 XP_011540936 XM_011542635 XP_011540937 XM_011542636 XP_011540938 XM_011542637 XP_011540939 XM_011542638 XP_011540940 XR_947796 XR_947797 XR_947798 XR_947799 XR_947800 NM_181645 NP_857596 |
Function | Key structural component of the deuterosome, a structure that promotes de novo centriole amplification in multiciliated cells. Deuterosome-mediated centriole amplification occurs in terminally differentiated multiciliated cells and can generate more than 100 centrioles. Probably sufficient for the specification and formation of the deuterosome inner core. Interacts with CEP152 and recruits PLK4 to activate centriole biogenesis (By similarity). {ECO:0000250}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Note=Localizes to the deuterosome. {ECO:0000250}. |
CCDC67 CRISPR/Cas9 KO Plasmid (h) - sc-414810 from Santa Cruz Biotechnology
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CCDC67 HDR Plasmid (h) - sc-414810-HDR from Santa Cruz Biotechnology
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CCDC67 Double Nickase Plasmid (h) - sc-414810-NIC from Santa Cruz Biotechnology
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CCDC67 Double Nickase Plasmid (h2) - sc-414810-NIC-2 from Santa Cruz Biotechnology
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CCDC67 CRISPR Activation Plasmid (h) - sc-414810-ACT from Santa Cruz Biotechnology
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CCDC67 CRISPR Activation Plasmid (h2) - sc-414810-ACT-2 from Santa Cruz Biotechnology
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CCDC67 Lentiviral Activation Particles (h) - sc-414810-LAC from Santa Cruz Biotechnology
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CCDC67 Lentiviral Activation Particles (h2) - sc-414810-LAC-2 from Santa Cruz Biotechnology
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CCDC67 siRNA (h) - sc-96673 from Santa Cruz Biotechnology
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CCDC67 shRNA Plasmid (h) - sc-96673-SH from Santa Cruz Biotechnology
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CCDC67 shRNA (h) Lentiviral Particles - sc-96673-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU097581 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN5552 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND5552 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR07260 from Sigma-Aldrich
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CCDC67 siRNA (Human) - CRJ5894 from Cohesion Biosciences
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CCDC67 - MBS8234955 from MyBioSource
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shRNA set against Human CCDC67 (NM_181645.3) - SHH256961 from Creative biogene
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shRNA set against Human CCDC67(NM_181645.3) - SHG149237 from Creative biogene
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Human CCDC67 siRNA - orb276395 from Biorbyt
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CCDC67 shRNA Plasmid (Human) - CHJ5894 from Cohesion Biosciences
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CCDC67 miRNA 3'UTR clone - MiUTR1H-01762 from Creative biogene
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