Gene Symbol | Polr2j |
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Entrez Gene | 20022 |
Alt Symbol | 14.5kDa, Polr2i, Rpb11a, Rpo2-4 |
Species | Mouse |
Gene Type | protein-coding |
Description | polymerase (RNA) II (DNA directed) polypeptide J |
Other Description | DNA-directed RNA polymerase II 13.3 kDa polypeptide|DNA-directed RNA polymerase II subunit J|DNA-directed RNA polymerase II subunit RPB11|RNA polymerase II 13.3 kDa subunit|RNA polymerase II 4 (14 kDa subunit)|RNA polymerase II subunit B11|RNA polymerase II subunit RPB14|RPB14|polymerase (RNA) II (DNA directed) polypeptide I |
Swissprots | O08740 |
Accessions | EDL19323 O08740 AK158610 BAE34581 AK158644 BAE34594 BC042939 AAH42939 D85818 BAA19918 DV065741 NM_011293 NP_035423 |
Function | DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000250}. |
Top Pathways | Huntington's disease, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism |
Polr2j CRISPR/Cas9 KO Plasmid (m) - sc-422734 from Santa Cruz Biotechnology
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Polr2j HDR Plasmid (m) - sc-422734-HDR from Santa Cruz Biotechnology
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Polr2j Double Nickase Plasmid (m) - sc-422734-NIC from Santa Cruz Biotechnology
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Polr2j Double Nickase Plasmid (m2) - sc-422734-NIC-2 from Santa Cruz Biotechnology
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Polr2j CRISPR Activation Plasmid (m) - sc-422734-ACT from Santa Cruz Biotechnology
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Polr2j CRISPR Activation Plasmid (m2) - sc-422734-ACT-2 from Santa Cruz Biotechnology
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Polr2j Lentiviral Activation Particles (m) - sc-422734-LAC from Santa Cruz Biotechnology
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Polr2j Lentiviral Activation Particles (m2) - sc-422734-LAC-2 from Santa Cruz Biotechnology
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Polr2j siRNA (m) - sc-152374 from Santa Cruz Biotechnology
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Polr2j shRNA Plasmid (m) - sc-152374-SH from Santa Cruz Biotechnology
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Polr2j shRNA (m) Lentiviral Particles - sc-152374-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU008791 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN39043 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND39043 from Sigma-Aldrich
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shRNA set against Mouse POLR2J (NM_011293.2) - SHH379488 from Creative biogene
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