Gene Symbol | TCN1 |
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Entrez Gene | 6947 |
Alt Symbol | HC, TC-1, TC1, TCI |
Species | Human |
Gene Type | protein-coding |
Description | transcobalamin I (vitamin B12 binding protein, R binder family) |
Other Description | haptocorin|haptocorrin|protein R|transcobalamin-1 |
Swissprots | A8KAC5 P20061 Q8WV77 |
Accessions | EAW73861 P20061 AK292990 BAF85679 BC018632 BC156607 AAI56608 BM769693 BM818792 BP370727 DQ892807 ABM83733 DQ896054 ABM87053 J05068 AAA61058 NM_001062 NP_001053 |
Function | Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach. |
Subcellular Location | Secreted. |
Tissue Specificity | Produced by the salivary glands of the oral cavity, in response to ingestion of food. Major constituent of secondary granules in neutrophils. {ECO:0000269|PubMed:2777761}. |
Transcobalamin I CRISPR/Cas9 KO Plasmid (h) - sc-408411 from Santa Cruz Biotechnology
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Transcobalamin I HDR Plasmid (h) - sc-408411-HDR from Santa Cruz Biotechnology
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Transcobalamin I Double Nickase Plasmid (h) - sc-408411-NIC from Santa Cruz Biotechnology
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Transcobalamin I Double Nickase Plasmid (h2) - sc-408411-NIC-2 from Santa Cruz Biotechnology
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Transcobalamin I CRISPR Activation Plasmid (h) - sc-408411-ACT from Santa Cruz Biotechnology
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Transcobalamin I CRISPR Activation Plasmid (h2) - sc-408411-ACT-2 from Santa Cruz Biotechnology
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Transcobalamin I Lentiviral Activation Particles (h) - sc-408411-LAC from Santa Cruz Biotechnology
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Transcobalamin I Lentiviral Activation Particles (h2) - sc-408411-LAC-2 from Santa Cruz Biotechnology
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Transcobalamin I siRNA (h) - sc-61706 from Santa Cruz Biotechnology
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Transcobalamin I shRNA Plasmid (h) - sc-61706-SH from Santa Cruz Biotechnology
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Transcobalamin I shRNA (h) Lentiviral Particles - sc-61706-V from Santa Cruz Biotechnology
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TCN1 RNAi - H00006947-R01 from Novus Biologicals
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MISSION® esiRNA - EHU142801 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN21159 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND21159 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR00598 from Sigma-Aldrich
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TCN1 siRNA (Human) - CRH4764 from Cohesion Biosciences
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TCN1 - MBS8206847 from MyBioSource
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shRNA set against Human TCN1 (NM_001062.3) - SHH425012 from Creative biogene
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TCN1 shRNA Plasmid (Human) - CHH4764 from Cohesion Biosciences
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TCN1 miRNA 3'UTR clone - MiUTR1H-10290 from Creative biogene
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