| Gene Symbol |
PLP1
|
| Entrez Gene |
5354
|
| Alt Symbol |
GPM6C, HLD1, MMPL, PLP, PLP/DM20, PMD, SPG2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
proteolipid protein 1
|
| Other Description |
lipophilin|major myelin proteolipid protein|myelin proteolipid protein
|
| Swissprots |
Q502Y1 Q6FHZ6 P60201
|
| Accessions |
AAA60350 AAB26927 AAB26928 AAD13880 BAA02577 BAA04110 CAA07364 CAA47050 EAW54690 EAW54691 EAW54692 EAW54693 EAW54694 P60201 AI205189 AK128782 AK292728 BAF85417 AK295374 BAG58333 AK295388 BAG58342 AK308966 AK309239 AK312340 BAG35261 AV731932 BC002665 AAH02665 BC095452 AAH95452 BQ717999 BQ723748 BT019601 AAV38408 BT019602 AAV38409 BX445448 CA389667 CR536542 CAG38779 DA299940 DC342197 DC342996 EB387051 M17085 AAA60118 M27110 AAA60117 M54927 AAA59565 NM_000533 NP_000524 NM_001128834 NP_001122306 NM_001305004 NP_001291933 NM_199478 NP_955772
|
| Function |
This is the major myelin protein from the central nervous system. It plays an important role in the formation or maintenance of the multilamellar structure of myelin.
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:24103481}; Multi-pass membrane protein {ECO:0000269|PubMed:24103481}. Myelin membrane {ECO:0000250}. Note=Colocalizes with SIRT2 in internodal regions, at paranodal axoglial junction and Schmidt-Lanterman incisures of myelin sheat. {ECO:0000250}.
|
![Western Blot: Myelin PLP Overexpression Lysate (Adult Normal) [NBL1-14523] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Myelin PLP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9353_Myelin%2520PLP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-14523-img0002.jpg)
![Western Blot: Myelin PLP Overexpression Lysate (Adult Normal) [NBP2-11114] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Myelin PLP.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/737_Myelin%2520PLP%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-11114-img0001.jpg)