Bcl2l1
| Gene Symbol | Bcl2l1 |
|---|---|
| Entrez Gene | 24888 |
| Alt Symbol | Bcl-xl, Bcl2l, Bclx, bcl-X |
| Species | Rat |
| Gene Type | protein-coding |
| Description | Bcl2-like 1 |
| Other Description | B cell lymphoma 2 like|B cell lymphoma like X|apoptosis regulator Bcl-X|bcl-2-like protein 1|bcl2-L-1 |
| Swissprots | Q64087 Q62836 P70614 P70613 Q62678 Q52KS0 P53563 Q64128 |
| Accessions | CAD42238 EDL86039 EDL86042 EDL86043 P53563 AF136230 AAD33683 AF279286 AAF81262 AY141038 AAN17784 BC094213 AAH94213 S76513 AAC60701 S78284 AAC60702 U34963 AAA77686 U72349 AAB17352 U72350 AAB17353 XM_006235264 XP_006235326 XM_006235265 XP_006235327 NM_001033670 NP_001028842 NM_001033671 NP_001028843 NM_001033672 NP_001028844 NM_031535 NP_113723 |
| Function | Isoform Bcl-X(S) promotes apoptosis. |
| Subcellular Location | Isoform Bcl-X(L): Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes to the centrosome when phosphorylated at Ser-49 (By similarity). After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. {ECO:0000250}. |
| Tissue Specificity | Expressed in most tissues. Bcl-X(beta) is specifically expressed in cerebellum, heart, and thymus. In the ovary, the predominant form is Bcl-X(L), with a small but detectable level of Bcl-X(S). |
| Top Pathways | Apoptosis, Toxoplasmosis, Pancreatic cancer, HTLV-I infection, Amyotrophic lateral sclerosis (ALS) |
Search more
