| Gene Symbol |
Bcl2l1
|
| Entrez Gene |
24888
|
| Alt Symbol |
Bcl-xl, Bcl2l, Bclx, bcl-X
|
| Species |
Rat
|
| Gene Type |
protein-coding
|
| Description |
Bcl2-like 1
|
| Other Description |
B cell lymphoma 2 like|B cell lymphoma like X|apoptosis regulator Bcl-X|bcl-2-like protein 1|bcl2-L-1
|
| Swissprots |
Q64087 Q62836 P70614 P70613 Q62678 Q52KS0 P53563 Q64128
|
| Accessions |
CAD42238 EDL86039 EDL86042 EDL86043 P53563 AF136230 AAD33683 AF279286 AAF81262 AY141038 AAN17784 BC094213 AAH94213 S76513 AAC60701 S78284 AAC60702 U34963 AAA77686 U72349 AAB17352 U72350 AAB17353 XM_006235264 XP_006235326 XM_006235265 XP_006235327 NM_001033670 NP_001028842 NM_001033671 NP_001028843 NM_001033672 NP_001028844 NM_031535 NP_113723
|
| Function |
Isoform Bcl-X(S) promotes apoptosis.
|
| Subcellular Location |
Isoform Bcl-X(L): Mitochondrion inner membrane. Mitochondrion outer membrane. Mitochondrion matrix. Cytoplasmic vesicle, secretory vesicle, synaptic vesicle membrane. Cytoplasm, cytosol. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome {ECO:0000250}. Nucleus membrane {ECO:0000250}; Single-pass membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Localizes to the centrosome when phosphorylated at Ser-49 (By similarity). After neuronal stimulation, translocates from cytosol to synaptic vesicle and mitochondrion membrane in a calmodulin-dependent manner. {ECO:0000250}.
|
| Tissue Specificity |
Expressed in most tissues. Bcl-X(beta) is specifically expressed in cerebellum, heart, and thymus. In the ovary, the predominant form is Bcl-X(L), with a small but detectable level of Bcl-X(S).
|
| Top Pathways |
Apoptosis, Toxoplasmosis, Pancreatic cancer, HTLV-I infection, Amyotrophic lateral sclerosis (ALS)
|