| Gene Symbol |
Dnah8
|
| Entrez Gene |
13417
|
| Alt Symbol |
ATPase, Dnahc8, Hst6.7b, P1-Loop
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
dynein, axonemal, heavy chain 8
|
| Other Description |
axonemal beta dynein heavy chain 8|axonemal dynein heavy chain 8 Dnahc8|ciliary dynein heavy chain 8|dynein heavy chain 8, axonemal|dynein, axon, heavy chain 8
|
| Swissprots |
Q3V0D2 Q91XP9 E9Q010 Q91XQ0 Q91XP8 Q99MH8 O08830 Q91V63 Q9QY72
|
| Accessions |
AAK18309 Q91XQ0 AF117305 AAF20213 AF356520 AAK60621 AF356521 AAK60622 AF356522 AAK60623 AF356523 AAK60624 AF363577 AAK60632 AF526535 AF526536 AK038133 AK133238 BAE21572 AK161258 BAE36274 BC032888 Z83817 CAB06071 XM_006523588 XP_006523651 XM_006523590 XP_006523653 XM_006523591 XP_006523654 XM_006523592 XP_006523655 NM_013811 NP_038839
|
| Function |
Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly. {ECO:0000269|PubMed:10602986, ECO:0000269|PubMed:12297094}.
|
| Subcellular Location |
Isoform 2: Cell projection, cilium, flagellum. Cytoplasm. Note=Detected in sperm tail, with almost exclusive localization to the principal piece. Also detected in the cytoplasm of primary spermatocytes. Location determined using antibody against peptide common to isoform 1 and isoform 2.
|
| Tissue Specificity |
Isoform 1 and/or isoform 2 are expressed in spermatocytes and mature sperm (at protein level). Testis- specific. Accumulates exclusively in mid to late spermatocytes. {ECO:0000269|PubMed:10602986, ECO:0000269|PubMed:12297094, ECO:0000269|PubMed:16054618}.
|
| Top Pathways |
Huntington's disease
|