| Gene Symbol |
LPCAT4
|
| Entrez Gene |
254531
|
| Alt Symbol |
AGPAT7, AYTL3, LPAAT-eta, LPEAT2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
lysophosphatidylcholine acyltransferase 4
|
| Other Description |
1-AGP acyltransferase 7|1-AGPAT 7|1-acylglycerol-3-phosphate O-acyltransferase 7 (lysophosphatidic acid acyltransferase, eta)|1-acylglycerophosphocholine O-acyltransferase|1-acylglycerophosphoserine O-acyltransferase|1-alkenylglycerophosphoethanolamine O-acyltransferase|1-alkylglycerophosphocholine O-acetyltransferase|PLSC domain containing protein|acyl-CoA:lysophosphatidylethanolamine acyltransferase 2|acyltransferase like 3|acyltransferase-like 3|lysophosphatidylethanolamine acyltransferase 2|lysophospholipid acyltransferase LPCAT4|plasmalogen synthase
|
| Swissprots |
Q7Z4P4 A8K2K8 Q8IUL7 O43412 Q8TB38 Q643R3
|
| Accessions |
EAW92306 EAW92307 EAW92308 Q643R3 AF007155 AAC19156 AF529233 AAP97722 AF542964 AAN33178 AK001119 AK290273 BAF82962 AK308910 AL832237 AY734233 AAU34184 BC024892 AAH24892 BC028209 BC048430 BC092463 AAH92463 BC144236 AAI44237 T29943 XM_006720454 XP_006720517 XM_011521422 XP_011519724 XR_243087 XR_243088 XR_931784 NM_153613 NP_705841
|
| Function |
Displays acyl-CoA-dependent lysophospholipid acyltransferase activity with a subset of lysophospholipids as substrates; converts lysophosphatidylethanolamine to phosphatidylethanolamine, lysophosphatidylcholine to phosphatidycholine, 1-alkenyl-lysophatidylethanolamine to 1- alkenyl-phosphatidylethanolamine, lysophosphatidylglycerol and alkyl-lysophosphatidylcholine to phosphatidylglycerol and alkyl- phosphatidylcholine, respectively. In contrast, has no lysophosphatidylinositol, glycerol-3-phosphate, diacylglycerol or lysophosphatidic acid acyltransferase activity. Prefers long chain acyl-CoAs (C16, C18) as acyl donors. {ECO:0000269|PubMed:18458083}.
|
| Subcellular Location |
Endoplasmic reticulum membrane {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}; Multi- pass membrane protein {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}.
|
| Tissue Specificity |
Widely expressed with predominant level in brain. {ECO:0000269|PubMed:16243729, ECO:0000269|PubMed:18458083}.
|
| Top Pathways |
Ether lipid metabolism, Glycerophospholipid metabolism
|