| Gene Symbol | DVL2 |
|---|---|
| Entrez Gene | 1856 |
| Alt Symbol | - |
| Species | Human |
| Gene Type | protein-coding |
| Description | dishevelled segment polarity protein 2 |
| Other Description | dishevelled 2 (homologous to Drosophila dsh)|dishevelled, dsh homolog 2|segment polarity protein dishevelled homolog DVL-2 |
| Swissprots | Q53XM0 O14641 D3DTN3 |
| Accessions | EAW90244 EAW90245 O14641 AF006012 AAB65243 AK026019 AK297099 BAG59612 AK297285 BAG59756 AK304229 BAG65098 AK309771 AK312829 BC014844 AAH14844 BG716400 BT009822 AAP88824 CB994349 JF432818 ADZ16035 XM_005256502 XP_005256559 XM_006721469 XP_006721532 NM_004422 NP_004413 |
| Function | Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). {ECO:0000250}. |
| Subcellular Location | Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). {ECO:0000250}. |
| Top Pathways | Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection |