| Gene Symbol |
DVL2
|
| Entrez Gene |
1856
|
| Alt Symbol |
-
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
dishevelled segment polarity protein 2
|
| Other Description |
dishevelled 2 (homologous to Drosophila dsh)|dishevelled, dsh homolog 2|segment polarity protein dishevelled homolog DVL-2
|
| Swissprots |
Q53XM0 O14641 D3DTN3
|
| Accessions |
EAW90244 EAW90245 O14641 AF006012 AAB65243 AK026019 AK297099 BAG59612 AK297285 BAG59756 AK304229 BAG65098 AK309771 AK312829 BC014844 AAH14844 BG716400 BT009822 AAP88824 CB994349 JF432818 ADZ16035 XM_005256502 XP_005256559 XM_006721469 XP_006721532 NM_004422 NP_004413
|
| Function |
Participates in Wnt signaling by binding to the cytoplasmic C-terminus of frizzled family members and transducing the Wnt signal to down-stream effectors. Promotes internalization and degradation of frizzled proteins upon Wnt signaling. Plays a role both in canonical and non-canonical Wnt signaling. Plays a role in the signal transduction pathways mediated by multiple Wnt genes (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Cell membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Cytoplasm, cytosol {ECO:0000250}. Cytoplasmic vesicle {ECO:0000250}. Note=Localizes at the cell membrane upon interaction with frizzled family members and promotes their internalization. Localizes to cytoplasmic puncta (By similarity). {ECO:0000250}.
|
| Top Pathways |
Wnt signaling pathway, Notch signaling pathway, Basal cell carcinoma, Melanogenesis, HTLV-I infection
|
![Western Blot: Dishevelled 2 Overexpression Lysate (Adult Normal) [NBL1-10063] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Dishevelled 2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/5241_Dishevelled%25202%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-10063-img0002.jpg)