| Gene Symbol | Vegfc |
|---|---|
| Entrez Gene | 114111 |
| Alt Symbol | - |
| Species | Rat |
| Gene Type | protein-coding |
| Description | vascular endothelial growth factor C |
| Other Description | VEGF-C|VRP|flt4 ligand|flt4-L|vascular endothelial growth factor-related protein |
| Swissprots | Q91ZE3 O35757 |
| Accessions | EDL78943 EDL78944 EDL78945 O35757 AF010302 AAB63248 AY032729 AAK96009 NM_053653 NP_446105 |
| Function | Growth factor active in angiogenesis, and endothelial cell growth, stimulating their proliferation and migration and also has effects on the permeability of blood vessels. May function in angiogenesis of the venous and lymphatic vascular systems during embryogenesis, and also in the maintenance of differentiated lymphatic endothelium in adults. Binds and activates VEGFR-2 (KDR/FLK1) and VEGFR-3 (FLT4) receptors. |
| Subcellular Location | Secreted. |
| Tissue Specificity | Highly expressed in the lung, ovary, preputial gland and the adrenal gland. Expressed in the post-pubertal mammary glands. {ECO:0000269|PubMed:10878616, ECO:0000269|PubMed:11683876}. |
| Top Pathways | Cytokine-cytokine receptor interaction, Focal adhesion, PI3K-Akt signaling pathway, Rap1 signaling pathway |