Gene Symbol | NOP58 |
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Entrez Gene | 51602 |
Alt Symbol | HSPC120, NOP5, NOP5/NOP58 |
Species | Human |
Gene Type | protein-coding |
Description | NOP58 ribonucleoprotein |
Other Description | NOP58 ribonucleoprotein homolog|nucleolar protein 5|nucleolar protein 58|nucleolar protein NOP5/NOP58 |
Swissprots | Q9UFN3 Q53SA4 Q6PK08 Q9P036 Q9Y2X3 |
Accessions | AAY24145 EAW70308 Q9Y2X3 AF123534 AAD27610 AF161469 AAF29084 AF263608 AAF91394 AK023975 BAG51244 AK300844 BAG62495 AK307396 AL117554 CAB55989 BC001707 BC009306 AAH09306 BC018805 BC032592 AAH32592 DQ586402 DQ890868 ABM81794 EU176490 ABW03291 NM_015934 NP_057018 |
Function | Required for 60S ribosomal subunit biogenesis (By similarity). Core component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles. Required for the biogenesis of box C/D snoRNAs such as U3, U8 and U14 snoRNAs. {ECO:0000250, ECO:0000269|PubMed:15574333, ECO:0000269|PubMed:17636026, ECO:0000269|PubMed:19620283}. |
Subcellular Location | Nucleus, nucleolus. Nucleus, nucleoplasm {ECO:0000305}. |
Tissue Specificity | Ubiquitous. |
Top Pathways | Ribosome biogenesis in eukaryotes |
Nop58 CRISPR/Cas9 KO Plasmid (h) - sc-405540 from Santa Cruz Biotechnology
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Nop58 HDR Plasmid (h) - sc-405540-HDR from Santa Cruz Biotechnology
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Nop58 Double Nickase Plasmid (h) - sc-405540-NIC from Santa Cruz Biotechnology
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Nop58 Double Nickase Plasmid (h2) - sc-405540-NIC-2 from Santa Cruz Biotechnology
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Nop58 CRISPR Activation Plasmid (h) - sc-405540-ACT from Santa Cruz Biotechnology
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Nop58 CRISPR Activation Plasmid (h2) - sc-405540-ACT-2 from Santa Cruz Biotechnology
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Nop58 Lentiviral Activation Particles (h) - sc-405540-LAC from Santa Cruz Biotechnology
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Nop58 Lentiviral Activation Particles (h2) - sc-405540-LAC-2 from Santa Cruz Biotechnology
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Nop58 siRNA (h) - sc-40907 from Santa Cruz Biotechnology
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Nop58 shRNA Plasmid (h) - sc-40907-SH from Santa Cruz Biotechnology
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Nop58 shRNA (h) Lentiviral Particles - sc-40907-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU016281 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN15416 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15416 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR01912 from Sigma-Aldrich
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NOP58 siRNA (Human) - CRH9853 from Cohesion Biosciences
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shRNA set against Human NOP58 (NM_015934.3) - SHH353720 from Creative biogene
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shRNA set against Human NOP5/NOP58(NM_015934.3) - SHR016278 from Creative biogene
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NOP58 shRNA Plasmid (Human) - CHH9853 from Cohesion Biosciences
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NOP58 miRNA 3'UTR clone - MiUTR1H-06850 from Creative biogene
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