KMT2D

Gene Symbol KMT2D
Entrez Gene 8085
Alt Symbol AAD10, ALR, CAGL114, KABUK1, KMS, MLL2, MLL4, TNRC21
Species Human
Gene Type protein-coding
Description lysine (K)-specific methyltransferase 2D
Other Description ALL1-related protein|Kabuki make-up syndrome|Kabuki mental retardation syndrome|histone-lysine N-methyltransferase 2D|histone-lysine N-methyltransferase MLL2|lysine N-methyltransferase 2D|myeloid/lymphoid or mixed-lineage leukemia 2|trinucleotide repeat containing 21
Swissprots O14686 O14687
Accessions EAW58034 EAW58035 EAW58036 O14686 AB209494 BAD92731 AF010403 AAC51734 AF010404 AAC51735 AL359940 AW997729 BC039197 AAH39197 BC040663 BF739070 BF876885 BF993837 BI031059 BX956541 CR749712 U80756 AAB91448 X85325 Y08267 CAA69593 XM_005269162 XP_005269219 XM_006719614 XP_006719677 XM_006719616 XP_006719679 XM_011538770 XP_011537072 XM_011538771 XP_011537073 XM_011538772 XP_011537074 XM_011538773 XP_011537075 XM_011538774 XP_011537076 XM_011538775 XP_011537077 XM_011538776 XP_011537078 XR_944740 NM_003482 NP_003473
Function Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:17851529}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.
Top Pathways Lysine degradation

MLL2 (H-300) - sc-292359 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

MLL2 (I-18) - sc-68671 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MLL2 (I-18): sc-68671. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebellum tissue showing nuclear envelope and nuclear staining of cells in granular layer and cells in molecular layer.

MLL2 (Q-17) - sc-68672 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
MLL2 (Q-17): sc-68672. Immunoperoxidase staining of formalin fixed, paraffin-embedded human cerebral cortex tissue showing nuclear and cytoplasmic staining of neuronal cells and nuclear staining of glial cells.

Anti-KMT2D / MLL2 antibody - ab15962 from Abcam

Prices $370.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
Immunohistochemical analysis of formalin-fixed, paraffin-embedded Human placenta tissue, staining KMT2B / MLL2 with ab15962 at 4 &microg/ml. Antigen retrieval was performed by heat mediation in a citrate buffer (pH 6).

Anti-KMT2D / MLL2 antibody - N-terminal - ab199271 from Abcam

Prices $376.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemical analysis of paraffin-embedded Human brain tissue labeling KMT2D / MLL2 with ab199271 at 1/40 dilution.

Anti-KMT2D / MLL2 Antibody (aa4720-4735) - LS-C3122 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa4712-4742, Biotin) - LS-C215797 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa4712-4742, Azide-free, HRP) - LS-C215800 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa1-44) - LS-C311584 from LifeSpan Bioscience

Prices $250.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa4712-4742, AP) - LS-C215796 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa4712-4742) - LS-C329835 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa4712-4742, APC) - LS-C215798 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa4712-4742, FITC) - LS-C215799 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa4712-4742, PE) - LS-C215801 from LifeSpan Bioscience

Prices $435.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-KMT2D / MLL2 Antibody (aa2-14) IHC-plus™ - LS-B8291 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Goat
Clonality Polyclonal
Anti-MLL2 antibody IHC of human spleen. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B8291 dilution 3.75 ug/ml.

Anti-KMT2D / MLL2 Antibody (clone 2E1) IHC-plus™ - LS-B11763 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone 2E1
Human Testis: Formalin-Fixed, Paraffin-Embedded (FFPE)

KMT2D Antibody - NBP1-89123 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunocytochemistry/Immunofluorescence: KMT2D Antibody [NBP1-89123] - Immunofluorescent staining of human cell line A-431 shows localization to nucleus, plasma membrane & cytosol.

KMT2D Antibody (2E1.) - H00008085-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E1.

FAD-linked sulfhydryl oxidase ALR Polyclonal Antibody - bs-1576R from Bioss

Prices $269.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-MLL2 (N-terminal) antibody produced in goat - SAB2501790 from Sigma-Aldrich

Prices $376.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MLL2 (N-terminal): <B>Cat. No. SAB2501790</B>: (4 μg/mL) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.

Anti-MLL2 antibody produced in rabbit - HPA035977 from Sigma-Aldrich

Prices $429.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
<B>Immunohistochemistry</B><BR/>Anti-MLL2: <B>Cat. No. HPA035977</B>: Immunohistochemical staining of human cerebral cortex shows strong nuclear membrane positivity in neuronal cells.

Monoclonal Anti-MLL2 antibody produced in mouse - SAB1402978 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2E1
<B>Immunoblotting</B><BR/>Monoclonal Anti-MLL2: <B>Cat. No. SAB1402978</B>: Antibody concentration: 1 μg/mL. Specific band of ~37.1 kDa using immunogen protein lysate.

Anti-MLL2 (C-term) antibody produced in rabbit - SAB1300327 from Sigma-Aldrich

Prices $291.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

MLL2-Antibody-C-term - AP6183a from Abgent, a WuXi AppTec company

Prices $99.00, $295.00
Sizes 80 µl, 400 µl
Host Rabbit
Clonality Polyclonal
Anti-MLL2 Antibody (T4720) at 1:27000 dilution + HMML2 recombinant protein Lysates/proteins at 20 µg per lane. Secondary Goat Anti-Rabbit IgG, (H+L), Peroxidase conjugated at 1/10000 dilution. Predicted band size : 12 kDa Blocking/Dilution buffer: 5% NFDM/TBST.

MLL2-Antibody-N-Term - AF2296a from Abgent, a WuXi AppTec company

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal
AF2296a (4 µg/ml) staining of paraffin embedded Human Placenta. Steamed antigen retrieval with citrate buffer pH 6, HRP-staining.
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