KMT2D

Gene Symbol KMT2D
Entrez Gene 8085
Alt Symbol AAD10, ALR, CAGL114, KABUK1, KMS, MLL2, MLL4, TNRC21
Species Human
Gene Type protein-coding
Description lysine (K)-specific methyltransferase 2D
Other Description ALL1-related protein|Kabuki make-up syndrome|Kabuki mental retardation syndrome|histone-lysine N-methyltransferase 2D|histone-lysine N-methyltransferase MLL2|lysine N-methyltransferase 2D|myeloid/lymphoid or mixed-lineage leukemia 2|trinucleotide repeat containing 21
Swissprots O14686 O14687
Accessions EAW58034 EAW58035 EAW58036 O14686 AB209494 BAD92731 AF010403 AAC51734 AF010404 AAC51735 AL359940 AW997729 BC039197 AAH39197 BC040663 BF739070 BF876885 BF993837 BI031059 BX956541 CR749712 U80756 AAB91448 X85325 Y08267 CAA69593 XM_005269162 XP_005269219 XM_006719614 XP_006719677 XM_006719616 XP_006719679 XM_011538770 XP_011537072 XM_011538771 XP_011537073 XM_011538772 XP_011537074 XM_011538773 XP_011537075 XM_011538774 XP_011537076 XM_011538775 XP_011537077 XM_011538776 XP_011537078 XR_944740 NM_003482 NP_003473
Function Histone methyltransferase. Methylates 'Lys-4' of histone H3 (H3K4me). H3K4me represents a specific tag for epigenetic transcriptional activation. Acts as a coactivator for estrogen receptor by being recruited by ESR1, thereby activating transcription. {ECO:0000269|PubMed:16603732, ECO:0000269|PubMed:17500065, ECO:0000269|PubMed:17851529}.
Subcellular Location Nucleus {ECO:0000305}.
Tissue Specificity Expressed in most adult tissues, including a variety of hematoipoietic cells, with the exception of the liver.
Top Pathways Lysine degradation

MLL2 CRISPR/Cas9 KO Plasmid (h) - sc-401659 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 HDR Plasmid (h) - sc-401659-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 Double Nickase Plasmid (h) - sc-401659-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 Double Nickase Plasmid (h2) - sc-401659-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 CRISPR Activation Plasmid (h) - sc-401659-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 CRISPR Activation Plasmid (h2) - sc-401659-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 Lentiviral Activation Particles (h) - sc-401659-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 Lentiviral Activation Particles (h2) - sc-401659-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

MLL2 siRNA (h) - sc-75794 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLL2 shRNA Plasmid (h) - sc-75794-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MLL2 shRNA (h) Lentiviral Particles - sc-75794-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

KMT2D RNAi - H00008085-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

KMT2B RNAi - H00009757-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU076961 from Sigma-Aldrich

Category siRNA
Prices $250.00
Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN14397 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND14397 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

KMT2D siRNA (Human) - CRH5362 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

shRNA set against Human MLL2 (NM_003482.3) - SHH342524 from Creative biogene

Category siRNA
Species Reactivities Human

KMT2D shRNA Plasmid (Human) - CHH5362 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

MLL2 miRNA 3'UTR clone - MiUTR1H-06324 from Creative biogene

Species Reactivities Human
Search more