| Gene Symbol |
KSR1
|
| Entrez Gene |
8844
|
| Alt Symbol |
KSR, RSU2
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
kinase suppressor of ras 1
|
| Other Description |
kinase suppressor of Ras 1
|
| Swissprots |
F8WEA9 Q13476 Q8IVT5 H7BYU0
|
| Accessions |
CAE84533 CAE84534 EAW51034 EAW51035 Q8IVT5 AK095721 AK124344 AK130719 BAC85413 BC035488 BC037586 BC042106 AAH42106 BC167812 AAI67812 BI829205 BX396814 U43586 AAC50354 XM_006722151 XP_006722214 XM_006722152 XP_006722215 XM_006722154 XP_006722217 XM_011525428 XP_011523730 XM_011525429 XP_011523731 XM_011525430 XP_011523732 XM_011525431 XP_011523733 XM_011525432 XP_011523734 XM_011525433 XP_011523735 XM_011525434 XP_011523736 XM_011525435 XP_011523737 XM_011525436 XP_011523738 XM_011525437 XP_011523739 XR_934587 XR_934588 XR_934589 NM_014238 NP_055053
|
| Function |
Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity.
|
| Subcellular Location |
Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery (By similarity). {ECO:0000250}.
|
| Top Pathways |
Tuberculosis
|