KSR1
| Gene Symbol | KSR1 |
|---|---|
| Entrez Gene | 8844 |
| Alt Symbol | KSR, RSU2 |
| Species | Human |
| Gene Type | protein-coding |
| Description | kinase suppressor of ras 1 |
| Other Description | kinase suppressor of Ras 1 |
| Swissprots | F8WEA9 Q13476 Q8IVT5 H7BYU0 |
| Accessions | CAE84533 CAE84534 EAW51034 EAW51035 Q8IVT5 AK095721 AK124344 AK130719 BAC85413 BC035488 BC037586 BC042106 AAH42106 BC167812 AAI67812 BI829205 BX396814 U43586 AAC50354 XM_006722151 XP_006722214 XM_006722152 XP_006722215 XM_006722154 XP_006722217 XM_011525428 XP_011523730 XM_011525429 XP_011523731 XM_011525430 XP_011523732 XM_011525431 XP_011523733 XM_011525432 XP_011523734 XM_011525433 XP_011523735 XM_011525434 XP_011523736 XM_011525435 XP_011523737 XM_011525436 XP_011523738 XM_011525437 XP_011523739 XR_934587 XR_934588 XR_934589 NM_014238 NP_055053 |
| Function | Location-regulated scaffolding protein connecting MEK to RAF. Promotes MEK and RAF phosphorylation and activity through assembly of an activated signaling complex. By itself, it has no demonstrated kinase activity. |
| Subcellular Location | Cytoplasm {ECO:0000269|PubMed:20679487}. Membrane {ECO:0000250}; Peripheral membrane protein {ECO:0000250}. Endoplasmic reticulum membrane {ECO:0000269|PubMed:20679487}. Note=In unstimulated cells, where the phosphorylated form is bound to a 14-3-3 protein, sequestration in the cytoplasm occurs. Following growth factor treatment, the protein is free for membrane translocation, and it moves from the cytoplasm to the cell periphery (By similarity). {ECO:0000250}. |
| Top Pathways | Tuberculosis |
Ksr-1 CRISPR/Cas9 KO Plasmid (h) - sc-401768 from Santa Cruz Biotechnology
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Ksr-1 HDR Plasmid (h) - sc-401768-HDR from Santa Cruz Biotechnology
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Ksr-1 Double Nickase Plasmid (h) - sc-401768-NIC from Santa Cruz Biotechnology
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Ksr-1 Double Nickase Plasmid (h2) - sc-401768-NIC-2 from Santa Cruz Biotechnology
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Ksr-1 CRISPR Activation Plasmid (h) - sc-401768-ACT from Santa Cruz Biotechnology
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Ksr-1 CRISPR Activation Plasmid (h2) - sc-401768-ACT-2 from Santa Cruz Biotechnology
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Ksr-1 Lentiviral Activation Particles (h) - sc-401768-LAC from Santa Cruz Biotechnology
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Ksr-1 Lentiviral Activation Particles (h2) - sc-401768-LAC-2 from Santa Cruz Biotechnology
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Ksr-1 siRNA (h) - sc-35762 from Santa Cruz Biotechnology
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Ksr-1 shRNA Plasmid (h) - sc-35762-SH from Santa Cruz Biotechnology
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Ksr-1 shRNA (h) Lentiviral Particles - sc-35762-V from Santa Cruz Biotechnology
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KSR1 RNAi - H00008844-R02 from Novus Biologicals
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MISSION® esiRNA - EHU139691 from Sigma-Aldrich
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MISSION® siRNA - SIHK1033 from Sigma-Aldrich
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MISSION® siRNA - SIHK1034 from Sigma-Aldrich
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MISSION® siRNA - SIHK1035 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1478 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1476 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1477 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1476 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1477 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1478 from Sigma-Aldrich
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KSR1 siRNA (Human) - CRH5840 from Cohesion Biosciences
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Ksr-1 siRNA (r) - sc-270592 from Santa Cruz Biotechnology
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Ksr-1 shRNA Plasmid (r) - sc-270592-SH from Santa Cruz Biotechnology
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