| Gene Symbol |
POU5F1
|
| Entrez Gene |
5460
|
| Alt Symbol |
OCT3, OCT4, OTF-3, OTF3, OTF4, Oct-3, Oct-4
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
POU class 5 homeobox 1
|
| Other Description |
POU domain transcription factor OCT4|POU domain, class 5, transcription factor 1|POU-type homeodomain-containing DNA-binding protein|octamer-binding protein 3|octamer-binding protein 4|octamer-binding transcription factor 3
|
| Swissprots |
A6NLL8 Q5STF4 Q15167 Q01860 D2IYK4 A6NCS1 Q5STF3 Q15168 P31359 Q16422
|
| Accessions |
ACZ95699 ACZ95700 AGG40970 AGG40971 AGG40974 BAB63311 BAC54946 BAE78630 BAF31281 EAX03366 EAX03367 EAX03368 Q01860 AA205411 AI811039 AM851115 CAO99189 AM851116 CAO99190 AM851117 CAO99191 AM851118 CAO99192 AM851119 CAO99193 AM851120 CAO99194 AM851121 CAO99195 AM851122 CAO99196 AM851123 CAO99197 AM851124 CAO99198 AM851125 CAO99199 AM851126 CAO99200 BC020712 BC069246 BC117435 AAI17436 BC117437 AAI17438 BQ278003 CD247724 DQ486514 DQ486515 DQ486516 DQ486517 EU518650 ACD14148 FM177951 CAQ76268 FM177952 CAQ76269 FM177953 CAQ76270 FM177954 CAQ76271 FM177955 CAQ76272 FM177956 CAQ76273 FM177957 CAQ76274 FM177958 CAQ76275 FM177959 CAQ76276 FM177960 CAQ76277 FM177961 CAQ76278 FM177962 CAQ76279 FM177963 CAQ76280 FM177964 CAQ76281 FM177965 CAQ76282 FM177968 CAQ76285 GU480808 ADE48539 GU480809 ADE48540 GU480810 GU480811 ADE48541 GU480812 ADE48542 GU480813 ADE48543 GU480815 ADE48544 GU480816 ADE48545 GU480817 ADE48546 GU480818 ADE48547 GU480819 ADE48548 GU480820 ADE48549 GU480821 ADE48550 GU480822 ADE48551 GU480823 ADE48552 GU480824 ADE48553 GU480825 ADE48554 GU480826 ADE48555 GU480827 ADE48556 GU480828 ADE48557 GU480829 ADE48558 GU480830 ADE48559 HQ122658 ADW77313 HQ122659 HQ122660 ADW77314 HQ122661 ADW77315 HQ122662 ADW77316 HQ122663 ADW77317 HQ122664 ADW77318 HQ122665 ADW77319 HQ122666 HQ122667 ADW77320 HQ122668 ADW77321 HQ122669 ADW77322 HQ122670 ADW77323 HQ122671 HQ122672 ADW77324 HQ122673 ADW77325 HQ122674 ADW77326 HQ122675 ADW77327 HQ258221 ADR82975 HQ258573 ADR83327 S81255 AAB35990 Z11898 CAA77951 Z11899 CAA77952 NM_001173531 NP_001167002 NM_001285986 NP_001272915 NM_001285987 NP_001272916 NM_002701 NP_002692 NM_203289 NP_976034
|
| Function |
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Forms a trimeric complex with SOX2 on DNA and controls the expression of a number of genes involved in embryonic development such as YES1, FGF4, UTF1 and ZFP206. Critical for early embryogenesis and for embryonic stem cell pluripotency. {ECO:0000269|PubMed:18035408}.
|
| Subcellular Location |
Cytoplasm. Nucleus. Note=Expressed in a diffuse and slightly punctuate pattern.
|
| Tissue Specificity |
Expressed in developing brain. Highest levels found in specific cell layers of the cortex, the olfactory bulb, the hippocampus and the cerebellum. Low levels of expression in adult tissues. {ECO:0000269|PubMed:1408763, ECO:0000269|PubMed:7908264}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|