| Gene Symbol |
ZBTB1
|
| Entrez Gene |
22890
|
| Alt Symbol |
ZNF909
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger and BTB domain containing 1
|
| Other Description |
zinc finger and BTB domain-containing protein 1
|
| Swissprots |
Q86SW8 A8K6S8 Q9Y2K1
|
| Accessions |
EAW80863 Q9Y2K1 AB023214 BAA76841 AK291743 BAF84432 AW965994 AY598321 AAT06732 BC050719 AAH50719 BM975910 BX248777 CAD66584 BX537646 CN362091 EU446779 ABZ92308 XM_005267410 XP_005267467 XM_005267411 XP_005267468 XM_011536566 XP_011534868 XM_011536567 XP_011534869 XM_011536568 XP_011534870 NM_001123329 NP_001116801 NM_014950 NP_055765
|
| Function |
Acts as a transcriptional repressor. Represses cAMP- responsive element (CRE)-mediated transcriptional activation. Involved in lymphoid lineage commitment and differentiation. Plays a key role in the instruction of early lymphoid progenitors to develop into T-cell lineage. {ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167}.
|
| Subcellular Location |
Nucleus. Nucleus, nucleoplasm. Note=Localized in dot-like structures in the nucleus. Colocalized with SMRT in nuclear bodies. The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies.
|