Gene Symbol | ZBTB1 |
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Entrez Gene | 22890 |
Alt Symbol | ZNF909 |
Species | Human |
Gene Type | protein-coding |
Description | zinc finger and BTB domain containing 1 |
Other Description | zinc finger and BTB domain-containing protein 1 |
Swissprots | Q86SW8 A8K6S8 Q9Y2K1 |
Accessions | EAW80863 Q9Y2K1 AB023214 BAA76841 AK291743 BAF84432 AW965994 AY598321 AAT06732 BC050719 AAH50719 BM975910 BX248777 CAD66584 BX537646 CN362091 EU446779 ABZ92308 XM_005267410 XP_005267467 XM_005267411 XP_005267468 XM_011536566 XP_011534868 XM_011536567 XP_011534869 XM_011536568 XP_011534870 NM_001123329 NP_001116801 NM_014950 NP_055765 |
Function | Acts as a transcriptional repressor. Represses cAMP- responsive element (CRE)-mediated transcriptional activation. Involved in lymphoid lineage commitment and differentiation. Plays a key role in the instruction of early lymphoid progenitors to develop into T-cell lineage. {ECO:0000269|PubMed:20797634, ECO:0000269|PubMed:21706167}. |
Subcellular Location | Nucleus. Nucleus, nucleoplasm. Note=Localized in dot-like structures in the nucleus. Colocalized with SMRT in nuclear bodies. The sumoylated form is preferentially located in the nucleoplasm outside the nuclear bodies. |
ZBTB1 CRISPR/Cas9 KO Plasmid (h) - sc-411630 from Santa Cruz Biotechnology
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ZBTB1 HDR Plasmid (h) - sc-411630-HDR from Santa Cruz Biotechnology
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ZBTB1 Double Nickase Plasmid (h) - sc-411630-NIC from Santa Cruz Biotechnology
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ZBTB1 Double Nickase Plasmid (h2) - sc-411630-NIC-2 from Santa Cruz Biotechnology
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ZBTB1 CRISPR Activation Plasmid (h) - sc-411630-ACT from Santa Cruz Biotechnology
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ZBTB1 CRISPR Activation Plasmid (h2) - sc-411630-ACT-2 from Santa Cruz Biotechnology
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ZBTB1 Lentiviral Activation Particles (h) - sc-411630-LAC from Santa Cruz Biotechnology
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ZBTB1 Lentiviral Activation Particles (h2) - sc-411630-LAC-2 from Santa Cruz Biotechnology
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ZBTB1 siRNA (h) - sc-92283 from Santa Cruz Biotechnology
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ZBTB1 shRNA Plasmid (h) - sc-92283-SH from Santa Cruz Biotechnology
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ZBTB1 shRNA (h) Lentiviral Particles - sc-92283-V from Santa Cruz Biotechnology
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ZBTB1 RNAi - H00022890-R01 from Novus Biologicals
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MISSION® esiRNA - EHU002521 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN23053 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND23053 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR10353 from Sigma-Aldrich
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ZBTB1 siRNA (Human) - CRH7846 from Cohesion Biosciences
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ZBTB1 - MBS8241356 from MyBioSource
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shRNA set against Human ZBTB1 (NM_014950.2) - SHH448900 from Creative biogene
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ZBTB1 shRNA Plasmid (Human) - CHH7846 from Cohesion Biosciences
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ZBTB1 miRNA 3'UTR clone - MiUTR3H-16626 from Creative biogene
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ZBTB1 miRNA 3'UTR clone - MiUTR3H-16627 from Creative biogene
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