| Gene Symbol |
SUMO1
|
| Entrez Gene |
7341
|
| Alt Symbol |
DAP1, GMP1, OFC10, PIC1, SENP2, SMT3, SMT3C, SMT3H3, UBL1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
small ubiquitin-like modifier 1
|
| Other Description |
GAP modifying protein 1|SMT3 homolog 3|SMT3 suppressor of mif two 3 homolog 1|sentrin|small ubiquitin-related modifier 1|ubiquitin-homology domain protein PIC1|ubiquitin-like protein SMT3C|ubiquitin-like protein UBL1
|
| Swissprots |
P55856 Q6FGG0 A8MUS8 Q93068 P63165 B2R4I5 Q6NZ62
|
| Accessions |
AAY24035 EAW70304 EAW70305 EAW70306 EAW70307 P63165 AA401634 AB062294 BAB93477 AI815216 AK311840 BAG34782 BC005899 BC006462 AAH06462 BC053528 AAH53528 BC066306 AAH66306 BG503431 BG569821 BQ930026 BT006632 AAP35278 BU532734 CA313671 CR542147 CAG46944 CR542156 CAG46953 DQ893210 ABM84136 DQ896156 ABM87155 U38784 AAC50733 U61397 AAB40388 U67122 AAC50996 U72722 AAB40390 U83117 AAB39999 X99586 CAA67898 NM_001005781 NP_001005781 NM_001005782 NP_001005782 NM_003352 NP_003343
|
| Function |
Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development. {ECO:0000269|PubMed:18408734, ECO:0000269|PubMed:18538659, ECO:0000269|PubMed:21965678, ECO:0000269|PubMed:9019411, ECO:0000269|PubMed:9162015}.
|
| Subcellular Location |
Nucleus membrane. Nucleus speckle. Cytoplasm. Nucleus, PML body. Note=Recruited by BCL11A into the nuclear body. {ECO:0000250}.
|
| Top Pathways |
RNA transport
|
![Western Blot: Sumo 1 Overexpression Lysate (Adult Normal) [NBL1-16612] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for Sumo 1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/8195_Sumo%25201%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16612-img0002.jpg)