GEMIN4

Gene Symbol	GEMIN4
Entrez Gene	50628
Alt Symbol	HC56, HCAP1, HHRF-1, p97
Species	Human
Gene Type	protein-coding
Description	gem (nuclear organelle) associated protein 4
Other Description	HCC-associated protein 1|component of gems 4|gem-associated protein 4|gemin-4
Swissprots	Q9UG32 Q9Y4Q2 P57678 Q9NZS7
Accessions	AAG24546 EAW90653 EAW90654 P57678 AF173856 AAF35283 AF177341 AAG17985 AK302722 BAG63941 AL080150 CAB45743 AL080167 CAB45755 BC020062 AAH20062 BC032084 BC036024 DB455185 EU832469 ACE87641 XM_005256667 XP_005256724 XM_005256668 XP_005256725 XM_005256670 XP_005256727 XM_011523910 XP_011522212 XM_011523911 XP_011522213 XM_011523912 XP_011522214 XM_011523913 XP_011522215 NM_015721 NP_056536
Function	The SMN complex plays a catalyst role in the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Thereby, plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. Dissociation by the SMN complex of CLNS1A from the trapped Sm proteins and their transfer to an SMN-Sm complex triggers the assembly of core snRNPs and their transport to the nucleus. {ECO:0000269|PubMed:18984161}.
Subcellular Location	Cytoplasm. Nucleus. Nucleus, nucleolus. Nucleus, gem. Note=Localized in subnuclear structures next to coiled bodies, called gems, which are highly enriched in spliceosomal snRNPs and in the nucleolus.
Top Pathways	RNA transport

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Gemin 4 peptide - ab32708 from Abcam Category Peptide

Human Gemin 4 peptide - ab32709 from Abcam Category Peptide

Human Gemin 4 protein fragment - ab162348 from Abcam Category Protein Source Wheat germ Species Human

Recombinant Human Gemin 4 Protein - H00050628-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

Gemin-4 - H00050628-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Gemin-4 - H00050628-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

GEMIN4 fusion protein - Ag13643 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

GEMIN4 fusion protein - ag3099 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human GEMIN4, His-tagged - GEMIN4-13222H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Proteasome 26S Subunit, Non ATPase 2 (PSMD2) - RPG279Hu01 from Cloud-clone Category Protein Source E.coli Species Human

Recombinant Human Gem-associated protein 4(GEMIN4) ,partial - CSB-YP009363HU CSB-EP009363HU CSB-BP009363HU CSB-MP009363HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

Gemin 4 Recombinant Protein Antigen - NBP2-49534PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E. coli Species Human

GEMIN4-Blocking-Peptide-N-term - BP20185a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

GEMIN4 Peptide, Human - M34GP06205H from Creative Peptides Category Peptide Source Synthetic. Species Human

Gem-associated protein 4 (GEMIN4), partial, Recombinant Protein - MBS953770 from MyBioSource Category Protein Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

Gemin 4 Recombinant Protein Antigen - NBP2-55998PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

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