| Gene Symbol | PCID2 |
|---|---|
| Entrez Gene | 55795 |
| Alt Symbol | F10 |
| Species | Human |
| Gene Type | protein-coding |
| Description | PCI domain containing 2 |
| Other Description | CSN12-like protein|PCI domain-containing protein 2 |
| Swissprots | Q9HBZ7 Q3ZCX1 Q9NW44 Q9NUK6 Q5JVF3 Q9NVY1 Q5TC58 Q5TC57 Q9H7K1 Q9NWH3 A6NK09 |
| Accessions | EAX09189 EAX09190 EAX09191 EAX09192 EAX09193 EAX09194 EAX09195 EAX09196 EAX09197 EAX09198 EAX09199 EAX09200 Q5JVF3 AA779868 AF183426 AAG09695 AI272719 AK000888 BAA91407 AK001185 BAA91542 AK001302 BAA91611 AK002167 BAA92118 AK023313 BAB14521 AK024478 BAB15768 AK098706 AK289462 BAF82151 AK309321 BC008975 AAH08975 BC016614 AAH16614 BC031246 AAH31246 BM932149 BP244753 DA058550 XM_005268324 XP_005268381 XM_005268325 XP_005268382 XM_011537510 XP_011535812 XM_011537511 XP_011535813 XM_011537512 XP_011535814 XM_011537513 XP_011535815 XM_011537514 XP_011535816 XM_011537515 XP_011535817 XM_011537516 XP_011535818 XM_011537517 XP_011535819 NM_001127202 NP_001120674 NM_001127203 NP_001120675 NM_001258212 NP_001245141 NM_001258213 NP_001245142 NM_018386 NP_060856 |
| Function | Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export- competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. Binds and stabilizes BRCA2 and is thus involved in the control of R-loop- associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2- depleted cells. {ECO:0000250, ECO:0000269|PubMed:22307388, ECO:0000269|PubMed:24896180}. |