| Gene Symbol |
Asxl1
|
| Entrez Gene |
228790
|
| Alt Symbol |
mKIAA0978
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
additional sex combs like 1
|
| Other Description |
additional sex combs-like protein 1|putative Polycomb group protein ASXL1
|
| Swissprots |
P59598
|
| Accessions |
P59598 AK079284 AK081063 AK122413 BAC65695 AK133095 BAE21508 AK141208 BC026205 BC059028 BC076565 BC172612 AAI72612 BC172725 AAI72725 BK005683 DAA05751 XM_006499330 XP_006499393 XM_011239483 XP_011237785 XM_011239484 XP_011237786 XM_011239485 XP_011237787 XM_011239486 XP_011237788 XM_011239487 XP_011237789 XR_374455 NM_001039939 NP_001035028
|
| Function |
Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). {ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:19880879, ECO:0000269|PubMed:21047783}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:19880879}.
|