Gene Symbol | Asxl1 |
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Entrez Gene | 228790 |
Alt Symbol | mKIAA0978 |
Species | Mouse |
Gene Type | protein-coding |
Description | additional sex combs like 1 |
Other Description | additional sex combs-like protein 1|putative Polycomb group protein ASXL1 |
Swissprots | P59598 |
Accessions | P59598 AK079284 AK081063 AK122413 BAC65695 AK133095 BAE21508 AK141208 BC026205 BC059028 BC076565 BC172612 AAI72612 BC172725 AAI72725 BK005683 DAA05751 XM_006499330 XP_006499393 XM_011239483 XP_011237785 XM_011239484 XP_011237786 XM_011239485 XP_011237787 XM_011239486 XP_011237788 XM_011239487 XP_011237789 XR_374455 NM_001039939 NP_001035028 |
Function | Probable Polycomb group (PcG) protein involved in transcriptional regulation mediated by ligand-bound retinoic acid receptors (RARs) and peroxisome proliferator-activated receptor gamma (PPARG). Acts as a coactivator of RARA and RXRA through association with NCOA1. Acts as a corepressor through recruitment of KDM1A and CBX5 to target genes in a cell-type specific manner; the function seems to involve differential recruitment of methylated histone H3 to respective promoters. Acts as a corepressor for PPARG and suppresses its adipocyte differentiation-inducing activity. Non-catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1). {ECO:0000269|PubMed:16606617, ECO:0000269|PubMed:19880879, ECO:0000269|PubMed:21047783}. |
Subcellular Location | Nucleus {ECO:0000269|PubMed:19880879}. |
ASXL1 CRISPR/Cas9 KO Plasmid (m) - sc-432808 from Santa Cruz Biotechnology
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ASXL1 HDR Plasmid (m) - sc-432808-HDR from Santa Cruz Biotechnology
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ASXL1 Double Nickase Plasmid (m) - sc-432808-NIC from Santa Cruz Biotechnology
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ASXL1 Double Nickase Plasmid (m2) - sc-432808-NIC-2 from Santa Cruz Biotechnology
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ASXL1 CRISPR Activation Plasmid (m) - sc-432808-ACT from Santa Cruz Biotechnology
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ASXL1 CRISPR Activation Plasmid (m2) - sc-432808-ACT-2 from Santa Cruz Biotechnology
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ASXL1 Lentiviral Activation Particles (m) - sc-432808-LAC from Santa Cruz Biotechnology
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ASXL1 Lentiviral Activation Particles (m2) - sc-432808-LAC-2 from Santa Cruz Biotechnology
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ASXL1 siRNA (m) - sc-141310 from Santa Cruz Biotechnology
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ASXL1 shRNA Plasmid (m) - sc-141310-SH from Santa Cruz Biotechnology
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ASXL1 shRNA (m) Lentiviral Particles - sc-141310-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU204691 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN27122 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND27122 from Sigma-Aldrich
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ASXL1 siRNA (Mouse) - CRN2680 from Cohesion Biosciences
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ASXL1 - MBS8234544 from MyBioSource
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shRNA set against Mouse ASXL1 (NM_001039939.1) - SHH241757 from Creative biogene
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Mouse ASXL1 siRNA - orb292155 from Biorbyt
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ASXL1 shRNA Plasmid (Mouse) - CHN2680 from Cohesion Biosciences
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ASXL1 miRNA 3'UTR clone - MiUTR1M-01765 from Creative biogene
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