| Gene Symbol |
ADAMTS1
|
| Entrez Gene |
9510
|
| Alt Symbol |
C3-C5, METH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
ADAM metallopeptidase with thrombospondin type 1 motif, 1
|
| Other Description |
A disintegrin and metalloproteinase with thrombospondin motifs 1|ADAM-TS 1|ADAM-TS1|ADAMTS-1|METH-1|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1|human metalloproteinase with thrombospondin type 1 motifs
|
| Swissprots |
Q9UHI8 D3DSD5 Q9P2K0 Q9UH83 Q9UP80 Q9NSJ8
|
| Accessions |
BAA95502 EAX09951 EAX09952 Q9UHI8 AB037767 BAA92584 AF060152 AAD48080 AF170084 AAF15317 AF207664 AAF23772 AK023795 AK129873 BAC85245 AK314475 BAG37080 AL162080 CAB82413 AW163724 BC036515 AAH36515 BX647388 CAI46043 DQ108407 AAZ73034 DQ896765 ABM87764 EU176454 ABW03905 NM_006988 NP_008919
|
| Function |
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. {ECO:0000250, ECO:0000269|PubMed:10438512}.
|
| Subcellular Location |
Secreted, extracellular space, extracellular matrix {ECO:0000250}.
|
![Western Blot: ADAMTS1 Overexpression Lysate (Adult Normal) [NBP2-07547] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for ADAMTS1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/9128_ADAMTS1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBP2-07547-img0001.jpg)