Gene Symbol | ADAMTS1 |
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Entrez Gene | 9510 |
Alt Symbol | C3-C5, METH1 |
Species | Human |
Gene Type | protein-coding |
Description | ADAM metallopeptidase with thrombospondin type 1 motif, 1 |
Other Description | A disintegrin and metalloproteinase with thrombospondin motifs 1|ADAM-TS 1|ADAM-TS1|ADAMTS-1|METH-1|a disintegrin-like and metalloprotease (reprolysin type) with thrombospondin type 1 motif, 1|human metalloproteinase with thrombospondin type 1 motifs |
Swissprots | Q9UHI8 D3DSD5 Q9P2K0 Q9UH83 Q9UP80 Q9NSJ8 |
Accessions | BAA95502 EAX09951 EAX09952 Q9UHI8 AB037767 BAA92584 AF060152 AAD48080 AF170084 AAF15317 AF207664 AAF23772 AK023795 AK129873 BAC85245 AK314475 BAG37080 AL162080 CAB82413 AW163724 BC036515 AAH36515 BX647388 CAI46043 DQ108407 AAZ73034 DQ896765 ABM87764 EU176454 ABW03905 NM_006988 NP_008919 |
Function | Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover (By similarity). Has angiogenic inhibitor activity. Active metalloprotease, which may be associated with various inflammatory processes as well as development of cancer cachexia. May play a critical role in follicular rupture. {ECO:0000250, ECO:0000269|PubMed:10438512}. |
Subcellular Location | Secreted, extracellular space, extracellular matrix {ECO:0000250}. |
ADAMTS-1 CRISPR/Cas9 KO Plasmid (h) - sc-402048 from Santa Cruz Biotechnology
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ADAMTS-1 HDR Plasmid (h) - sc-402048-HDR from Santa Cruz Biotechnology
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ADAMTS-1 Double Nickase Plasmid (h) - sc-402048-NIC from Santa Cruz Biotechnology
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ADAMTS-1 Double Nickase Plasmid (h2) - sc-402048-NIC-2 from Santa Cruz Biotechnology
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ADAMTS-1 CRISPR Activation Plasmid (h) - sc-402048-ACT from Santa Cruz Biotechnology
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ADAMTS-1 CRISPR Activation Plasmid (h2) - sc-402048-ACT-2 from Santa Cruz Biotechnology
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ADAMTS-1 Lentiviral Activation Particles (h) - sc-402048-LAC from Santa Cruz Biotechnology
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ADAMTS-1 Lentiviral Activation Particles (h2) - sc-402048-LAC-2 from Santa Cruz Biotechnology
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ADAMTS-1 siRNA (h) - sc-41425 from Santa Cruz Biotechnology
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ADAMTS-1 shRNA Plasmid (h) - sc-41425-SH from Santa Cruz Biotechnology
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ADAMTS-1 shRNA (h) Lentiviral Particles - sc-41425-V from Santa Cruz Biotechnology
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ADAMTS1 RNAi - H00009510-R01 from Novus Biologicals
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MISSION® esiRNA - EHU156111 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN2825 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND2825 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08923 from Sigma-Aldrich
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ADAMTS1 siRNA (Human) - CRH6317 from Cohesion Biosciences
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ADAMTS1 - MBS8231712 from MyBioSource
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shRNA set against Human ADAMTS1 (NM_006988.3) - SHH231726 from Creative biogene
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shRNA set against Human ADAMTS1(NM_006988.3) - SHG039493 from Creative biogene
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ADAMTS1 shRNA Plasmid (Human) - CHH6317 from Cohesion Biosciences
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ADAMTS1 miRNA 3'UTR clone - MiUTR1H-00166 from Creative biogene
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