CTLA4

Gene Symbol	CTLA4
Entrez Gene	1493
Alt Symbol	ALPS5, CD, CD152, CELIAC3, CTLA-4, GRD4, GSE, IDDM12
Species	Human
Gene Type	protein-coding
Description	cytotoxic T-lymphocyte-associated protein 4
Other Description	CD152 isoform|celiac disease 3|cytotoxic T lymphocyte associated antigen 4 short spliced form|cytotoxic T-lymphocyte protein 4|cytotoxic T-lymphocyte-associated serine esterase-4|insulin-dependent diabetes mellitus 12|ligand and transmembrane spliced cytotoxic T lymphocyte associated antigen 4
Swissprots	Q5S005 E9PDH0 Q9UKN9 Q53TD5 P16410 Q0PP65 O95653 Q8WXJ1 A0N1S0 Q96P43 Q52MC1
Accessions	AAA52127 AAF02499 AAK13084 AAL40932 AAX93176 ABC67470 ABG78999 ABG79000 ADV60197 ADV60198 ADV60199 ADV60200 CAY55959 EAW70354 P16410 AF414120 AAL07473 AF486806 AAL96664 AK313732 BAG36473 AY209009 AAO17066 AY792514 AAV66331 AY999702 AAY00166 BC069566 AAH69566 BC070162 AAH70162 BC074842 AAH74842 BC074893 AAH74893 BG058720 CD639535 DQ785106 ABG85285 L15006 AAB59385 U90273 AAD00698 XR_241294 NM_001037631 NP_001032720 NM_005214 NP_005205
Function	Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28. {ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1714933}.
Subcellular Location	Cell membrane {ECO:0000269|PubMed:18468488}; Single-pass type I membrane protein {ECO:0000269|PubMed:18468488}. Note=Exists primarily an intracellular antigen whose surface expression is tightly regulated by restricted trafficking to the cell surface and rapid internalisation;.
Tissue Specificity	Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation. {ECO:0000269|PubMed:10493833, ECO:0000269|PubMed:16551244, ECO:0000269|PubMed:1713603}.
Top Pathways	T cell receptor signaling pathway, Cell adhesion molecules (CAMs), Autoimmune thyroid disease, Rheumatoid arthritis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CTLA-4 (C-19) - sc-1628 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Goat Clonality Polyclonal

CTLA-4 (F-8) - sc-376016 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Mouse Clonality Monoclonal

CTLA-4 (H-126) - sc-9094 from Santa Cruz Biotechnology Prices $279.00 Sizes 200 µg/ml Host Rabbit Clonality Polyclonal

Anti-CTLA4 antibody - ab135038 from Abcam Prices $376.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

Anti-CTLA4 antibody - ab107198 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CTLA4 antibody - ab102730 from Abcam Prices $376.00 Sizes 400 µl Host Rabbit Clonality Polyclonal

Anti-CTLA4 antibody [AT4F2] - ab177523 from Abcam Prices $376.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone AT4F2

Anti-CTLA4 antibody [BNI3] - ab19792 from Abcam Prices $378.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone BNI3

Anti-CTLA4 antibody [BNI3] - Low endotoxin, Azide free - ab197134 from Abcam Prices $372.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone BNI3

Anti-CTLA4 antibody [EPR1476] - ab134090 from Abcam Prices $379.00 Sizes 100 µl Host Rabbit Clonality Monoclonal Clone EPR1476

Anti-CTLA4 antibody [KT50] (HRP) - ab106490 from Abcam Prices $368.00 Sizes 100 µl Host Mouse Clonality Monoclonal Clone KT50

Anti-CTLA4 antibody [KT56] - ab110650 from Abcam Prices $376.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone KT56

Anti-CTLA4 antibody [MM0206-8F16] - ab89211 from Abcam Prices $370.00 Sizes 100 µg Host Mouse Clonality Monoclonal Clone MM0206-8F16

Anti-CTLA4 / CD152 Antibody (aa189-219, PE) - LS-C226720 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (clone AT4F2) - LS-C200843 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone AT4F2

Anti-CTLA4 / CD152 Antibody (aa57-86, AP) - LS-C226804 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (aa57-86, FITC) - LS-C226806 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (aa57-86, APC) - LS-C226805 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (aa57-86, PE) - LS-C226809 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (aa57-86, Azide-free, HRP) - LS-C226807 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (aa57-86, Biotin) - LS-C226817 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (aa52-211, Biotin) - LS-C298419 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (aa41-192, Biotin) - LS-C297654 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Anti-CTLA4 / CD152 Antibody (clone 2F1) - LS-C196996 from LifeSpan Bioscience Host Mouse Clonality Monoclonal Clone 2F1

Anti-CTLA4 / CD152 Antibody (aa45-185, Biotin) - LS-C300013 from LifeSpan Bioscience Host Rabbit Clonality Polyclonal

Search more