| Gene Symbol |
Wdr83
|
| Entrez Gene |
67836
|
| Alt Symbol |
1500041N16Rik, Morg1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
WD repeat domain containing 83
|
| Other Description |
MAPK cascade scaffold protein|MAPK organizer 1|WD repeat domain-containing protein 83|mitogen-activated protein kinase organizer 1
|
| Swissprots |
Q9D235 Q505C2 Q99JX9 Q8VEB7 Q9DAJ4
|
| Accessions |
EDL10996 EDL10997 EDL10998 Q9DAJ4 AK005790 BAB24241 AK020654 BAB32164 AY365434 AAQ64635 BC005587 AAH05587 BC019369 AAH19369 BC020047 BC034842 BC094624 AAH94624 DQ556650 NM_026399 NP_080675
|
| Function |
Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:15118098}.
|
| Subcellular Location |
Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}.
|
| Tissue Specificity |
Ubiquitous. {ECO:0000269|PubMed:15118098}.
|