Gene Symbol | Wdr83 |
---|---|
Entrez Gene | 67836 |
Alt Symbol | 1500041N16Rik, Morg1 |
Species | Mouse |
Gene Type | protein-coding |
Description | WD repeat domain containing 83 |
Other Description | MAPK cascade scaffold protein|MAPK organizer 1|WD repeat domain-containing protein 83|mitogen-activated protein kinase organizer 1 |
Swissprots | Q9D235 Q505C2 Q99JX9 Q8VEB7 Q9DAJ4 |
Accessions | EDL10996 EDL10997 EDL10998 Q9DAJ4 AK005790 BAB24241 AK020654 BAB32164 AY365434 AAQ64635 BC005587 AAH05587 BC019369 AAH19369 BC020047 BC034842 BC094624 AAH94624 DQ556650 NM_026399 NP_080675 |
Function | Molecular scaffold protein for various multimeric protein complexes. Involved in response to hypoxia by acting as a negative regulator of HIF1A/HIF-1-alpha via its interaction with EGLN3/PHD3. May promote degradation of HIF1A. May act by recruiting signaling complexes to a specific upstream activator (By similarity). Also acts as a module in the assembly of a multicomponent scaffold for the ERK pathway, linking ERK responses to specific agonists. At low concentrations it enhances ERK activation, whereas high concentrations lead to the inhibition of ERK activation. May also be involved in pre-mRNA splicing. {ECO:0000250, ECO:0000269|PubMed:15118098}. |
Subcellular Location | Cytoplasm {ECO:0000250}. Nucleus {ECO:0000250}. Note=Predominantly cytoplasmic. Partially nuclear. {ECO:0000250}. |
Tissue Specificity | Ubiquitous. {ECO:0000269|PubMed:15118098}. |
MORG1 CRISPR/Cas9 KO Plasmid (m) - sc-426764 from Santa Cruz Biotechnology
|
||||||||
MORG1 HDR Plasmid (m) - sc-426764-HDR from Santa Cruz Biotechnology
|
||||||||
MORG1 Double Nickase Plasmid (m) - sc-426764-NIC from Santa Cruz Biotechnology
|
||||||||
MORG1 Double Nickase Plasmid (m2) - sc-426764-NIC-2 from Santa Cruz Biotechnology
|
||||||||
MORG1 CRISPR Activation Plasmid (m) - sc-426764-ACT from Santa Cruz Biotechnology
|
||||||||
MORG1 CRISPR Activation Plasmid (m2) - sc-426764-ACT-2 from Santa Cruz Biotechnology
|
||||||||
MORG1 Lentiviral Activation Particles (m) - sc-426764-LAC from Santa Cruz Biotechnology
|
||||||||
MORG1 Lentiviral Activation Particles (m2) - sc-426764-LAC-2 from Santa Cruz Biotechnology
|
||||||||
MORG1 siRNA (m) - sc-75813 from Santa Cruz Biotechnology
|
||||||||
MORG1 shRNA Plasmid (m) - sc-75813-SH from Santa Cruz Biotechnology
|
||||||||
MORG1 shRNA (m) Lentiviral Particles - sc-75813-V from Santa Cruz Biotechnology
|
||||||||
MISSION® esiRNA - EMU064931 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit - CKOZFN44615 from Sigma-Aldrich
|
||||||||
CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND44615 from Sigma-Aldrich
|
||||||||
WDR83 siRNA (Mouse) - CRM7368 from Cohesion Biosciences
|
||||||||
WDR83 - MBS8212248 from MyBioSource
|
||||||||
shRNA set against Mouse WDR83 (NM_026399.2) - SHH446584 from Creative biogene
|
||||||||
shRNA set against Mouse 1500041N16Rik(NM_026399.2) - SHG002717 from Creative biogene
|
||||||||
WDR83 shRNA Plasmid (Mouse) - CHM7368 from Cohesion Biosciences
|
||||||||
WDR83 miRNA 3'UTR clone - MiUTR1M-00135 from Creative biogene
|