| Gene Symbol | CASP7 |
|---|---|
| Entrez Gene | 840 |
| Alt Symbol | CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 |
| Species | Human |
| Gene Type | protein-coding |
| Description | caspase 7, apoptosis-related cysteine peptidase |
| Other Description | ICE-like apoptotic protease 3|apoptotic protease MCH-3|caspase 7, apoptosis-related cysteine protease|caspase-7 |
| Swissprots | Q5SVL0 Q53YD5 D3DRB8 B4DQU7 Q5SVL3 Q96BA0 B5BU45 P55210 Q13364 |
| Accessions | CAV28504 EAW49494 EAW49495 EAW49496 EAW49497 EAW49498 P55210 AB451281 BAG70095 AB451413 BAG70227 AK223489 AK298964 BAG61059 AK300578 BAG62277 AK301437 BAG62964 AU130224 BC015799 AAH15799 BM976488 BP429646 BQ006259 BQ007179 BT006683 AAP35329 BX487250 BX647973 DC332144 DC364916 DC384804 DQ890614 ABM92231 DQ893769 ABM84695 EU831939 ACE87380 EU832034 ACE86696 U37448 AAC50303 U37449 AAC50304 U39613 AAC50346 U40281 AAC50352 U67206 AAF21460 U67320 AAC51153 XM_006718017 XP_006718080 XM_006718018 XP_006718081 XM_011540259 XP_011538561 XM_011540260 XP_011538562 NM_001227 NP_001218 NM_001267056 NP_001253985 NM_001267057 NP_001253986 NM_001267058 NP_001253987 NM_033338 NP_203124 NM_033339 NP_203125 NM_033340 NP_203126 |
| Function | Involved in the activation cascade of caspases responsible for apoptosis execution. Cleaves and activates sterol regulatory element binding proteins (SREBPs). Proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly- 217' bond. Overexpression promotes programmed cell death. |
| Subcellular Location | Cytoplasm. |
| Tissue Specificity | Highly expressed in lung, skeletal muscle, liver, kidney, spleen and heart, and moderately in testis. No expression in the brain. |
| Top Pathways | Apoptosis, Alzheimer's disease, Pertussis, Legionellosis, TNF signaling pathway |
caspase-7 CRISPR/Cas9 KO Plasmid (h) - sc-401301 from Santa Cruz Biotechnology
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caspase-7 HDR Plasmid (h) - sc-401301-HDR from Santa Cruz Biotechnology
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caspase-7 Double Nickase Plasmid (h) - sc-401301-NIC from Santa Cruz Biotechnology
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caspase-7 Double Nickase Plasmid (h2) - sc-401301-NIC-2 from Santa Cruz Biotechnology
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caspase-7 CRISPR Activation Plasmid (h) - sc-401301-ACT from Santa Cruz Biotechnology
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caspase-7 CRISPR Activation Plasmid (h2) - sc-401301-ACT-2 from Santa Cruz Biotechnology
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caspase-7 Lentiviral Activation Particles (h) - sc-401301-LAC from Santa Cruz Biotechnology
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caspase-7 Lentiviral Activation Particles (h2) - sc-401301-LAC-2 from Santa Cruz Biotechnology
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caspase-7 siRNA (h) - sc-29929 from Santa Cruz Biotechnology
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caspase-7 shRNA Plasmid (h) - sc-29929-SH from Santa Cruz Biotechnology
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caspase-7 shRNA (h) Lentiviral Particles - sc-29929-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EHU090761 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN1968 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND1968 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR09294 from Sigma-Aldrich
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CASP7 siRNA (Human) - CRH0594 from Cohesion Biosciences
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CASP7 - MBS828537 from MyBioSource
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shRNA set against Human CASP7 (NM_001227.4) - SHH255013 from Creative biogene
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Human CASP7 siRNA - orb261096 from Biorbyt
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CASP7 shRNA Plasmid (Human) - CHH0594 from Cohesion Biosciences
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CASP7 miRNA 3'UTR clone - MiUTR3H-04391 from Creative biogene
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CASP7 miRNA 3'UTR clone - MiUTR3H-04392 from Creative biogene
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CASP7 miRNA 3'UTR clone - MiUTR3H-04393 from Creative biogene
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CASP7 miRNA 3'UTR clone - MiUTR3H-04394 from Creative biogene
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