NEDD8

Gene Symbol	NEDD8
Entrez Gene	4738
Alt Symbol	NEDD-8
Species	Human
Gene Type	protein-coding
Description	neural precursor cell expressed, developmentally down-regulated 8
Other Description	neddylin|ubiquitin-like protein Nedd8
Swissprots	Q6LES6 Q3SXN8 Q15843
Accessions	CDM22114 Q15843 AK125214 BC038290 BC064899 BC104200 AAI04201 BC104201 AAI04202 BC104664 AAI04665 BE548741 CF130271 CR407662 CAG28590 D23662 BAA04889 NM_006156 NP_006147
Function	Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. {ECO:0000269|PubMed:10318914, ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:11953428}.
Subcellular Location	Nucleus {ECO:0000269|PubMed:9353319}. Note=Mainly nuclear.
Tissue Specificity	Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:9353319}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human-NEDD8-cDNA-Clone - DC09342 from Abgent, a WuXi AppTec company Prices $109.35 Sizes 10 µg Species Human Accession NM_006156

NEDD8 - MBS1276575 from MyBioSource Prices $175.00 Sizes 10ug plasmid + 200ul glycerol stock Species Human Accession BC104201

Human NEDD8 Gene ORF cDNA clone in cloning vector - HG15620-G from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, N-GFPSpark tag - HG15620-ANG from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, N-Flag tag - HG15620-NF from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, C-GFPSpark tag - HG15620-ACG from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid - HG15620-UT from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, N-HA tag - HG15620-NY from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, C-Flag tag - HG15620-CF from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, C-OFPSpark tag - HG15620-ACR from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, N-OFPSpark tag - HG15620-ANR from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, N-Myc tag - HG15620-NM from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, C-Myc tag - HG15620-CM from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, N-His tag - HG15620-NH from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, C-HA tag - HG15620-CY from Sino Biological Species Human

Human NEDD8 Gene ORF cDNA clone expression plasmid, C-His tag - HG15620-CH from Sino Biological Species Human

Human NEDD8 ORF Clone (BC104201) - CDCS412578 from Creative biogene Species Human Accession Q15843

Human NEDD8 ORF clone (BC104201) - CDCB157996 from Creative biogene Species Human

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