NEDD8

Gene Symbol NEDD8
Entrez Gene 4738
Alt Symbol NEDD-8
Species Human
Gene Type protein-coding
Description neural precursor cell expressed, developmentally down-regulated 8
Other Description neddylin|ubiquitin-like protein Nedd8
Swissprots Q6LES6 Q3SXN8 Q15843
Accessions CDM22114 Q15843 AK125214 BC038290 BC064899 BC104200 AAI04201 BC104201 AAI04202 BC104664 AAI04665 BE548741 CF130271 CR407662 CAG28590 D23662 BAA04889 NM_006156 NP_006147
Function Ubiquitin-like protein which plays an important role in cell cycle control and embryogenesis. Covalent attachment to its substrates requires prior activation by the E1 complex UBE1C- APPBP1 and linkage to the E2 enzyme UBE2M. Attachment of NEDD8 to cullins activates their associated E3 ubiquitin ligase activity, and thus promotes polyubiquitination and proteasomal degradation of cyclins and other regulatory proteins. {ECO:0000269|PubMed:10318914, ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:11953428}.
Subcellular Location Nucleus {ECO:0000269|PubMed:9353319}. Note=Mainly nuclear.
Tissue Specificity Highly expressed in heart, skeletal muscle, spleen, thymus, prostate, testis, ovary, colon and leukocytes. {ECO:0000269|PubMed:10597293, ECO:0000269|PubMed:9353319}.

NEDD8 CRISPR/Cas9 KO Plasmid (h) - sc-417924 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 HDR Plasmid (h) - sc-417924-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 Double Nickase Plasmid (h) - sc-417924-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 Double Nickase Plasmid (h2) - sc-417924-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 CRISPR Activation Plasmid (h) - sc-417924-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 CRISPR Activation Plasmid (h2) - sc-417924-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 Lentiviral Activation Particles (h) - sc-417924-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 Lentiviral Activation Particles (h2) - sc-417924-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

NEDD8 siRNA (h) - sc-36026 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEDD8 shRNA Plasmid (h) - sc-36026-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEDD8 shRNA (h) Lentiviral Particles - sc-36026-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

NEDD8 RNAi - H00004738-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

MISSION® esiRNA - EHU112521 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN15188 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND15188 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

NEDD8 siRNA (Human) - CRH3147 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human NEDD8 siRNA - orb263649 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

NEDD8 shRNA Plasmid (Human) - CHH3147 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

NEDD8 miRNA 3'UTR clone - MiUTR1H-06711 from Creative biogene

Species Reactivities Human
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