DERL1

Gene Symbol DERL1
Entrez Gene 79139
Alt Symbol DER-1, DER1
Species Human
Gene Type protein-coding
Description derlin 1
Other Description DERtrin-1|Der1-like domain family, member 1|degradation in endoplasmic reticulum protein 1|derlin-1
Swissprots B3KW41 Q9BUN8 E9PH19
Accessions CAH25951 CBJ06471 EAW92013 EAW92014 EAW92015 EAW92016 EAW92017 Q9BUN8 AA976062 AF116708 AAF71128 AF131854 AI755206 AK023846 AK124086 BAG54003 AK303826 BAG64773 AK313675 BAG36426 AY358818 AAQ89177 BC002457 AAH02457 BC037174 BC050691 DA800358 DA906855 HQ447233 ADQ31720 XM_006716657 XP_006716720 XM_011517299 XP_011515601 NM_001134671 NP_001128143 NM_024295 NP_077271
Function Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}; Multi- pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}.
Tissue Specificity Ubiquitous. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
Top Pathways Amyotrophic lateral sclerosis (ALS), Protein processing in endoplasmic reticulum

Derlin-1 Antibody - 8897 from Cell Signaling Technology

Prices $239.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts from 293T cells, either mock transfected (-) or transfected with a Myc/DDK-tagged cDNA expression construct encoding full-length human Derlin-1 (hDerlin-1-Myc/DDK; +), using Derlin-1 Antibody.

Derlin-1 (N-20) - sc-46913 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Derlin-1 (N-20): sc-46913. Western blot analysis of Derlin-1 expression in U-937 whole cell lysate.

Derlin-1 (H-47) - sc-99204 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Derlin-1 (H-47): sc-99204. Western blot analysis of Derlin-1 expression in U-937 whole cell lysate.

Anti-DERL1 antibody - ab54545 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DERL1 antibody - C-terminal - ab93341 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
ab93341 stained HeLa cells. The cells were 100% methanol fixed for 5 minutes at -20°C and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1hour at room temperature to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab93341 at 5µg/ml) overnight at +4°C. The secondary antibody (pseudo-colored green) was Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) preadsorbed (ab150081) used at a 1/1000 dilution for 1hour at room temperature. Alexa Fluor® 594 WGA was used to label plasma membranes (pseudo-colored red) at a 1/200 dilution for 1hour at room temperature. DAPI was used to stain the cell nuclei (pseudo-colored blue) at a concentration of 1.43µM for 1hour at room temperature.

Anti-DERL1 / Derlin 1 Antibody (aa200-251) IHC-plus™ - LS-B494 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-DERL1 antibody IHC of human liver. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B494 concentration 10 ug/ml.

Anti-DERL1 / Derlin 1 Antibody - LS-C179914 from LifeSpan Bioscience

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (aa134-233) - LS-C307223 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus) - LS-C327181 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus) - LS-C345329 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot of DERL1 Antibody with human MCF7 Whole Cell lysate.

Anti-DERL1 / Derlin 1 Antibody (aa201-251) - LS-C289560 from LifeSpan Bioscience

Prices $375.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Detection of Human Derlin-1 by Immunohistochemistry. Sample: FFPE section of human ovarian carcinoma. Antibody: Affinity purified rabbit anti-Derlin-1 used at a dilution of 1:200 (1 ug/ml). Detection: Vector Laboratories ImmPACT NovaRED Peroxidase Substrate.

Anti-DERL1 / Derlin 1 Antibody (aa224-251) IHC-plus™ - LS-B9896 from LifeSpan Bioscience

Prices $395.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
Anti-DERL1 / DERLIN 1 antibody IHC staining of human small intestine. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval.

Anti-DERL1 / Derlin 1 Antibody (N-Terminus) - LS-C46966 from LifeSpan Bioscience

Prices $295.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, DY650) - LS-C141166 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus) - LS-C64677 from LifeSpan Bioscience

Prices $455.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, Biotin) - LS-C141165 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, DY488) - LS-C141167 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, DY550) - LS-C141169 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / DERLIN 1 Antibody (C-Terminus, HRP) - LS-C141168 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus) - LS-C144814 from LifeSpan Bioscience

Prices $365.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus) - LS-C153434 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, AP) - LS-C276740 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, APC) - LS-C276741 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, FITC) - LS-C276742 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-DERL1 / Derlin 1 Antibody (C-Terminus, PE) - LS-C276744 from LifeSpan Bioscience

Prices $515.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal
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