DERL1

Gene Symbol	DERL1
Entrez Gene	79139
Alt Symbol	DER-1, DER1
Species	Human
Gene Type	protein-coding
Description	derlin 1
Other Description	DERtrin-1|Der1-like domain family, member 1|degradation in endoplasmic reticulum protein 1|derlin-1
Swissprots	B3KW41 Q9BUN8 E9PH19
Accessions	CAH25951 CBJ06471 EAW92013 EAW92014 EAW92015 EAW92016 EAW92017 Q9BUN8 AA976062 AF116708 AAF71128 AF131854 AI755206 AK023846 AK124086 BAG54003 AK303826 BAG64773 AK313675 BAG36426 AY358818 AAQ89177 BC002457 AAH02457 BC037174 BC050691 DA800358 DA906855 HQ447233 ADQ31720 XM_006716657 XP_006716720 XM_011517299 XP_011515601 NM_001134671 NP_001128143 NM_024295 NP_077271
Function	Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In case of infection by cytomegaloviruses, it plays a central role in the export from the ER and subsequent degradation of MHC class I heavy chains via its interaction with US11 viral protein, which recognizes and associates with MHC class I heavy chains. Also participates in the degradation process of misfolded cytomegalovirus US2 protein. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856}.
Subcellular Location	Endoplasmic reticulum membrane {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}; Multi- pass membrane protein {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:15215856, ECO:0000269|PubMed:16186509, ECO:0000269|PubMed:16449189}.
Tissue Specificity	Ubiquitous. {ECO:0000269|PubMed:15215855, ECO:0000269|PubMed:16449189}.
Top Pathways	Amyotrophic lateral sclerosis (ALS), Protein processing in endoplasmic reticulum

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human DERL1 full length protein - ab163984 from Abcam Category Protein Source Wheat germ Species Human

Human DERL1 protein fragment - ab163985 from Abcam Category Protein Source Wheat germ Species Human

DERL1 / Derlin 1 Antibody Blocking Peptide - LS-E9756 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Derlin 1 Blocking Peptide - NB100-448PEP from Novus Biologicals Category Peptide Prices $69.00 Sizes 50 µg Species Human

Derlin 1 Partial Recombinant Protein - H00079139-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

DERL1-Antibody-C-term-Blocking-Peptide - BP8745b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Der P1 protein - orb81525 from Biorbyt Category Protein Prices $323.00, $595.00, $961.00 Sizes 100 μg, 500 μg, 1000 μg

Derlin-1 - H00079139-P01 from Acris Antibodies Category Protein Prices $340.00 Sizes 2 µg Species Human

Derlin-1 - H00079139-P01-10 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

Derlin-1 - H00079139-P01-25 from Acris Antibodies Category Protein Prices $520.00 Sizes 25 µg Species Human

Derlin-1 - H00079139-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Derlin-1 - H00079139-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

Der P1 Protein Recombinant - 228-10319-1 from RayBiotech Category Protein Prices $231.00 Sizes 1 µg Source Escherichia Coli.

Recombinant DERL1 - 228-10319-2 from RayBiotech Category Protein Prices $668.00 Sizes 2 µg

Recombinant DERL1 - 228-10319-3 from RayBiotech Category Protein Prices $1,190.00 Sizes 3 µg

DERL1 fusion protein - ag13974 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human Derlin 1 Protein - H00079139-P01 from Novus Biologicals Category Protein Prices $250.00 Sizes 2 µg Source Wheat Germ Species Human

DERL1 Protein - abx163338 from Abbexa Category Protein Species Human, Mouse

Derlin 1 Recombinant Protein Antigen - NBP1-88023PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

DERL1 Peptide, Human - M34GP04230H from Creative Peptides Category Peptide Source Synthetic. Species Human

Derlin-1 (DERL1), Recombinant Protein - MBS7013709 from MyBioSource Category Protein Prices $1,065.00, $2,050.00, $3,260.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Derlin-1 (DERL1), Recombinant Protein - MBS7013711 from MyBioSource Category Protein Prices $1,065.00, $2,050.00, $3,260.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Orangutan

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