| Gene Symbol | ATP5O |
|---|---|
| Entrez Gene | 539 |
| Alt Symbol | ATPO, OSCP |
| Species | Human |
| Gene Type | protein-coding |
| Description | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
| Other Description | ATP synthase subunit O, mitochondrial|human ATP synthase OSCP subunit|oligomycin sensitivity conferral protein|oligomycin sensitivity conferring protein |
| Swissprots | P48047 B2R4E2 Q6IBI2 Q5U042 |
| Accessions | EAX09802 EAX09803 EAX09804 P48047 AF088071 AK093795 AK124187 AK222608 BAD96328 AK222962 BAD96682 AK311796 BAG34739 AV734214 AW518473 BC021233 AAH21233 BC022865 AAH22865 BT019836 AAV38639 CD174837 CR456822 CAG33103 DQ656021 DQ656022 JF432864 ADZ16081 S77356 AAB34321 X83218 CAA58219 X83219 NM_001697 NP_001688 |
| Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. |
| Subcellular Location | Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. |
| Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |