Gene Symbol | ATP5O |
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Entrez Gene | 539 |
Alt Symbol | ATPO, OSCP |
Species | Human |
Gene Type | protein-coding |
Description | ATP synthase, H+ transporting, mitochondrial F1 complex, O subunit |
Other Description | ATP synthase subunit O, mitochondrial|human ATP synthase OSCP subunit|oligomycin sensitivity conferral protein|oligomycin sensitivity conferring protein |
Swissprots | P48047 B2R4E2 Q6IBI2 Q5U042 |
Accessions | EAX09802 EAX09803 EAX09804 P48047 AF088071 AK093795 AK124187 AK222608 BAD96328 AK222962 BAD96682 AK311796 BAG34739 AV734214 AW518473 BC021233 AAH21233 BC022865 AAH22865 BT019836 AAV38639 CD174837 CR456822 CAG33103 DQ656021 DQ656022 JF432864 ADZ16081 S77356 AAB34321 X83218 CAA58219 X83219 NM_001697 NP_001688 |
Function | Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. |
Subcellular Location | Mitochondrion {ECO:0000250}. Mitochondrion inner membrane {ECO:0000250}. |
Top Pathways | Alzheimer's disease, Huntington's disease, Oxidative phosphorylation |
Human ATP5O full length protein - ab104549 from Abcam
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ATP5O Antibody Blocking Peptide - LS-E16711 from LifeSpan Bioscience
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ATP5O Antibody Blocking Peptide - LS-E9643 from LifeSpan Bioscience
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ATP5O Recombinant Protein - H00000539-P01 from Novus Biologicals
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Recombinant Human ATP5O Protein - NBP1-50931 from Novus Biologicals
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ATP5O-Antibody-N-term-Blocking-Peptide - BP8563a from Abgent, a WuXi AppTec company
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Recombinant human ATP synthase subunit O, mitochondrial (OPCA00497) - OPCA00497 from Aviva Systems Biology
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Human ATP5O protein - orb245168 from Biorbyt
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Human ATP5O protein - orb167945 from Biorbyt
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ATPO Blocking Peptide - 33R-3081 from Fitzgerald
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ATP synthase subunit O (24-213, His-tag) - AR09787PU-L from Acris Antibodies
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ATP synthase subunit O (24-213, His-tag) - AR09787PU-N from Acris Antibodies
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ATP synthase subunit O - H00000539-P01-10 from Acris Antibodies
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ATP synthase subunit O - H00000539-P01-25 from Acris Antibodies
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ATP Synthase Subunit O, Mitochondrial, Human Recombinant - 228-12195-1 from RayBiotech
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Recombinant Human ATP Synthase Subunit O, Mitochondrial - 228-12195-2 from RayBiotech
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Recombinant Human ATP Synthase Subunit O, Mitochondrial - 228-12195-3 from RayBiotech
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ATP5O, 24-213aa, Human, His tag, E.coli - 01-1830-O from ARP American Research Products
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ATP5O fusion protein - Ag1458 from Proteintech Group
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ATP5O Human - ENPS-050 from NeoScientific
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Recombinant Human Mitochondrial ATP Synthase Subunit O - BP000899-ENZ-043 from Syd Labs
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ATP5O Human Protein - GWB-BSP134 from Genway Biotech
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ATP5O, 24-213aa, Recombinant Protein - GWB-P1191H from Genway Biotech
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Recombinant Human ATP5O, 24-213 aa, His-tagged - ATP5O-950H from Creative Biomart
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Recombinant Human ATP5O, His-tagged - ATP5O-27062TH from Creative Biomart
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