SMC1A

Gene Symbol SMC1A
Entrez Gene 8243
Alt Symbol CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
Species Human
Gene Type protein-coding
Description structural maintenance of chromosomes 1A
Other Description SMC protein 1A|SMC-1-alpha|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|segregation of mitotic chromosomes 1|structural maintenance of chromosomes protein 1A
Swissprots Q16351 Q2M228 O14995 Q14683
Accessions CAI42089 CAI42645 CAI42646 EAW93149 EAW93150 EAW93151 Q14683 AF176781 AAQ13659 AK055575 AK056308 AK091458 AK291921 BAF84610 AK301266 BAH13445 BC064368 AAH64368 BC080185 AAH80185 BC112127 AAI12128 BC171726 BP312805 BQ232418 BX640922 CAE45960 D80000 BAA11495 HQ258690 ADR83441 S78271 AAB34405 NM_001281463 NP_001268392 NM_006306 NP_006297
Function Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}.
Subcellular Location Nucleus {ECO:0000269|PubMed:12199140}. Chromosome {ECO:0000269|PubMed:12199140}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12199140}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.
Top Pathways Cell cycle, Oocyte meiosis

Mouse/Human SMC1A / SMC1 ELISA Kit (Cell-Based ELISA) - LS-F2316 from LifeSpan Bioscience

Category ELISA Kit
Prices $450.00
Sizes 1 plate

Mouse/Human/Rat Phospho-SMC1A / SMC1 (Ser966) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1221 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Mouse/Human Phospho-SMC1A / SMC1 (Ser957) ELISA Kit (Cell-Based Phosphorylation ELISA) - LS-F1619 from LifeSpan Bioscience

Category ELISA Kit
Prices $550.00
Sizes 1 plate

Rabbit anti-Phospho SMC1 (S966) Antibody, Affinity Purified - PLA0015 from Sigma-Aldrich

Prices $345.00
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-Phospho SMC1 (S966) Antibody, Affinity Purified: <B>Cat. No. PLA0015</B>: Detection of Human Phospho SMC1 (S966) by Immunohistochemistry. Sample: FFPE section of Human breast carcinoma. Antibody: Affinity purified Rabbit Anti-Phospho SMC1 (S966) (<B>Cat. No. PLA0015</B>) used at a dilution of 1:1,000 (1 μg/mL). Detection: DAB

Rabbit anti-SMC1 Antibody, Affinity Purified - PLA0017 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunohistochemistry</B><BR/>Rabbit Anti-SMC1 Antibody, Affinity Purified: <B>Cat. No. PLA0017</B>: Detection of Human SMC1 by Immunohistochemistry. Sample: FFPE section of Human breast carcinoma. Antibody: Affinity purified Rabbit Anti-SMC1 (<B>Cat. No. PLA0017</B>) used at a dilution of 1:1,000 (1 μg/mL). Detection: DAB

Rabbit anti-Phospho SMC1 (S957) Antibody, Affinity Purified - PLA0012 from Sigma-Aldrich

Prices $345.00
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

Goat anti-SMC1 Antibody, Affinity Purified - PLA0291 from Sigma-Aldrich

Prices $323.50
Sizes 100 µl
<B>Immunofluorescence</B>: This antibody is qualified for the Proximity Ligation Assay (PLA). The above image shows representative results for PLA using three color fluorescence, including DAPI stained nuclei (blue), phalloidin stained cytoplasmic F-actin (green), and PLA positive signal (red).

SMC1 Colorimetric Cell-Based ELISA Kit - CB5642 from Assay Biotechnology

Category ELISA Kit
Prices $380.00, $760.00, $1,140.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

SMC1 (Phospho-Ser966) Colorimetric Cell-Based ELISA Kit - CBP1215 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

SMC1 (Phospho-Ser957) Colorimetric Cell-Based ELISA Kit - CBP1674 from Assay Biotechnology

Category ELISA Kit
Prices $480.00, $960.00, $1,440.00
Sizes 1 kit, 2 kits, 3 kits
Range > 5000 Cells

structural maintenance of chromosomes 1A, ELISA Kit - MBS9323671 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

SMC1 ELISA Kit - DEIA-XYA1648 from Creative Diagnostics

Category ELISA Kit

SMC1 (Phospho-Ser957) ELISA Kit - DEIA-XYA1649 from Creative Diagnostics

Category ELISA Kit

SMC1 (Phospho-Ser966) ELISA Kit - DEIA-XYA1650 from Creative Diagnostics

Category ELISA Kit

Human SMC1A ELISA Kit - E036824 from Biobool

Category ELISA Kit

anti-SMC1A antibody (N-term) - ARG54011 from Arigo Biolaboratories

Category ELISA Kit

anti-SMC1A antibody (C-term) - ARG54012 from Arigo Biolaboratories

Category ELISA Kit

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9354405 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9347313 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9344534 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9346372 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9347396 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9364990 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9362277 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Structural Maintenance of Chromosomes 1A (SMC1A), ELISA Kit - MBS9358487 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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