| Gene Symbol |
SMC1A
|
| Entrez Gene |
8243
|
| Alt Symbol |
CDLS2, DXS423E, SB1.8, SMC1, SMC1L1, SMC1alpha, SMCB
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
structural maintenance of chromosomes 1A
|
| Other Description |
SMC protein 1A|SMC-1-alpha|SMC1 (structural maintenance of chromosomes 1, yeast)-like 1|segregation of mitotic chromosomes 1|structural maintenance of chromosomes protein 1A
|
| Swissprots |
Q16351 Q2M228 O14995 Q14683
|
| Accessions |
CAI42089 CAI42645 CAI42646 EAW93149 EAW93150 EAW93151 Q14683 AF176781 AAQ13659 AK055575 AK056308 AK091458 AK291921 BAF84610 AK301266 BAH13445 BC064368 AAH64368 BC080185 AAH80185 BC112127 AAI12128 BC171726 BP312805 BQ232418 BX640922 CAE45960 D80000 BAA11495 HQ258690 ADR83441 S78271 AAB34405 NM_001281463 NP_001268392 NM_006306 NP_006297
|
| Function |
Involved in chromosome cohesion during cell cycle and in DNA repair. Central component of cohesin complex. The cohesin complex is required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. The cohesin complex may also play a role in spindle pole assembly during mitosis. Involved in DNA repair via its interaction with BRCA1 and its related phosphorylation by ATM, or via its phosphorylation by ATR. Works as a downstream effector both in the ATM/NBS1 branch and in the ATR/MSH2 branch of S-phase checkpoint. {ECO:0000269|PubMed:11877377}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:12199140}. Chromosome {ECO:0000269|PubMed:12199140}. Chromosome, centromere, kinetochore {ECO:0000269|PubMed:12199140}. Note=Associates with chromatin. Before prophase it is scattered along chromosome arms. During prophase, most of cohesin complexes dissociate from chromatin probably because of phosphorylation by PLK, except at centromeres, where cohesin complexes remain. At anaphase, the RAD21 subunit of the cohesin complex is cleaved, leading to the dissociation of the complex from chromosomes, allowing chromosome separation. In germ cells, cohesin complex dissociates from chromatin at prophase I, and may be replaced by a meiosis-specific cohesin complex. The phosphorylated form on Ser-957 and Ser-966 associates with chromatin during G1/S/G2 phases but not during M phase, suggesting that phosphorylation does not regulate cohesin function. Integral component of the functional centromere- kinetochore complex at the kinetochore region during mitosis.
|
| Top Pathways |
Cell cycle, Oocyte meiosis
|
![Western Blot: SMC1 Overexpression Lysate (Adult Normal) [NBL1-16236] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for SMC1.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/2829_SMC1%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-16236-img0002.jpg)