| Gene Symbol |
NRIP1
|
| Entrez Gene |
8204
|
| Alt Symbol |
RIP140
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor interacting protein 1
|
| Other Description |
nuclear factor RIP140|nuclear receptor-interacting protein 1|receptor interacting protein 140|receptor-interacting protein 140
|
| Swissprots |
Q8IWE8 P48552
|
| Accessions |
AAF35255 AAF62185 CAB90396 CAD34981 EAX10047 P48552 AK123818 AK289786 BAF82475 BC040361 AAH40361 BE792046 DQ891180 ABM82106 DQ894362 ABM85288 HF584749 CCQ44046 HF584750 CCQ44047 X84373 CAA59108 XM_005261063 XP_005261120 XM_005261065 XP_005261122 XM_011529747 XP_011528049 XM_011529748 XP_011528050 XM_011529749 XP_011528051 XM_011529750 XP_011528052 XM_011529751 XP_011528053 XM_011529752 XP_011528054 NM_003489 NP_003480
|
| Function |
Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of ARNTL/BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. {ECO:0000269|PubMed:10364267, ECO:0000269|PubMed:11509661, ECO:0000269|PubMed:11518808, ECO:0000269|PubMed:12554755, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:21628546, ECO:0000269|PubMed:7641693}.
|
| Subcellular Location |
Nucleus {ECO:0000269|PubMed:11266503, ECO:0000269|PubMed:12773562, ECO:0000269|PubMed:15060175, ECO:0000269|PubMed:7641693}. Note=Localized to discrete foci and redistributes to larger nuclear domains upon binding to ligand- bound NR3C1.
|
![Western Blot: RIP140 Overexpression Lysate (Adult Normal) [NBL1-13793] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for RIP140.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/837_RIP140%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-13793-img0002.jpg)