| Gene Symbol |
APLF
|
| Entrez Gene |
200558
|
| Alt Symbol |
APFL, C2orf13, PALF, Xip1, ZCCHH1
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
aprataxin and PNKP like factor
|
| Other Description |
PNK and APTX-like FHA domain-containing protein|PNK and APTX-like FHA protein|XRCC1-interacting protein 1|aprataxin and PNK-like factor|aprataxin- and PNK-like factor|apurinic-apyrimidinic endonuclease APLF|zinc finger, CX5CX6HX5H motif containing 1
|
| Swissprots |
Q53P47 Q53PB9 A8K476 Q8IW19 Q53QU0
|
| Accessions |
AAY14945 AAY24008 AAY24113 EAW99871 EAW99872 Q8IW19 AK290841 BAF83530 AK308186 BC030711 BC041144 AAH41144 DA641644 NM_173545 NP_775816
|
| Function |
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150}.
|
| Subcellular Location |
Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.
|
![Western Blot: APLF Overexpression Lysate (Adult Normal) [NBL1-08402] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for APLF.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_1/13472_APLF%2520Overexpression%2520Lysate%2520%2528Adult%2520Normal%2529-Western%2520Blot-NBL1-08402-img0002.jpg)