APLF

Gene Symbol	APLF
Entrez Gene	200558
Alt Symbol	APFL, C2orf13, PALF, Xip1, ZCCHH1
Species	Human
Gene Type	protein-coding
Description	aprataxin and PNKP like factor
Other Description	PNK and APTX-like FHA domain-containing protein|PNK and APTX-like FHA protein|XRCC1-interacting protein 1|aprataxin and PNK-like factor|aprataxin- and PNK-like factor|apurinic-apyrimidinic endonuclease APLF|zinc finger, CX5CX6HX5H motif containing 1
Swissprots	Q53P47 Q53PB9 A8K476 Q8IW19 Q53QU0
Accessions	AAY14945 AAY24008 AAY24113 EAW99871 EAW99872 Q8IW19 AK290841 BAF83530 AK308186 BC030711 BC041144 AAH41144 DA641644 NM_173545 NP_775816
Function	Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic- apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage. {ECO:0000269|PubMed:17353262, ECO:0000269|PubMed:17396150}.
Subcellular Location	Nucleus. Cytoplasm, cytosol. Note=Localizes to DNA damage sites. Accumulates at single-strand breaks and double-strand breaks via the PBZ-type zinc fingers.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APLF peptide - ab59796 from Abcam Category Peptide Prices $181.00 Sizes 100 µg

APLF / PALF Antibody Blocking Peptide - LS-E23769 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

APLF fusion protein - ag5525 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

APLF fusion protein - ag5736 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

Recombinant Human APLF, GST-tagged - APLF-9742H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant Human APLF - APLF-1033H from Creative Biomart Category Protein Source Mammalian Cells Species Human

Recombinant Human Aprataxin and PNK-like factor(APLF) - CSB-YP814212HU CSB-EP814212HU CSB-BP814212HU CSB-MP814212HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

APLF - TP307936 from Acris Antibodies Category Protein Prices $680.00 Sizes 20 µg Source HEK293 cells Species Human

APLF (full length, C-term DDK tag) - TP710318 from Acris Antibodies Category Protein Prices $399.00 Sizes 20 µg Source SF9 cells Species Human

Aprataxin and PNK-like factor(APLF) , Recombinant Protein - MBS1459831 from MyBioSource Category Protein Prices $2,140.00, $2,140.00, $2,600.00, $2,600.00 Sizes 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Human

APLF Recombinant Protein Antigen - NBP2-38212PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

APLF Recombinant Protein Antigen - NBP1-86806PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

APLF Peptide, Human - M34GP00759H from Creative Peptides Category Peptide Source Synthetic. Species Human

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