Gene Symbol | NFIL3 |
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Entrez Gene | 4783 |
Alt Symbol | E4BP4, IL3BP1, NF-IL3A, NFIL3A |
Species | Human |
Gene Type | protein-coding |
Description | nuclear factor, interleukin 3 regulated |
Other Description | E4 promoter-binding protein 4|interleukin-3 promoter transcriptional activator|interleukin-3-binding protein 1|nuclear factor interleukin 3 regulated protein|nuclear factor interleukin-3-regulated protein|transcriptional activator NF-IL3A |
Swissprots | Q96HS0 B2R9Y8 Q6FGQ8 Q14211 Q16649 |
Accessions | ABK15691 EAW62796 EAW62797 Q16649 AK313970 BAG36685 AW163045 BC008197 AAH08197 BQ937243 CR542049 CAG46846 DB256817 DQ891105 ABM82031 HM204564 ADK11690 HQ447282 ADQ31769 HY038941 S79880 AAB35410 U26173 AAA93067 X64318 CAA45597 NM_001289999 NP_001276928 NM_001290000 NP_001276929 NM_005384 NP_005375 |
Function | Acts as a transcriptional regulator that recognizes and binds to the sequence 5'-[GA]TTA[CT]GTAA[CT]-3', a sequence present in many cellular and viral promoters. Represses transcription from promoters with activating transcription factor (ATF) sites. Represses promoter activity in osteoblasts (By similarity). Represses transcriptional activity of PER1 (By similarity). Represses transcriptional activity of PER2 via the B- site on the promoter (By similarity). Activates transcription from the interleukin-3 promoter in T-cells. Competes for the same consensus-binding site with PAR DNA-binding factors (DBP, HLF and TEF) (By similarity). Component of the circadian clock that acts as a negative regulator for the circadian expression of PER2 oscillation in the cell-autonomous core clock (By similarity). Protects pro-B cells from programmed cell death (By similarity). {ECO:0000250}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00978}. |
Tissue Specificity | Expressed in bladder stomach, thyroid, spinal cord, lymph node, trachea, adrenal gland, bone marrow and muscle. {ECO:0000269|PubMed:10942106}. |
Human NFIL3 full length protein - ab131816 from Abcam
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Human NFIL3 peptide - ab103932 from Abcam
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Human NFIL3 peptide - ab22793 from Abcam
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NFIL3 Antibody Blocking Peptide - LS-E4390 from LifeSpan Bioscience
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NFIL3 Antibody Blocking Peptide - LS-E10863 from LifeSpan Bioscience
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NFIL3 Antibody Blocking Peptide - LS-E25258 from LifeSpan Bioscience
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NFIL3 Antibody Blocking Peptide - LS-E13898 from LifeSpan Bioscience
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Recombinant Human NFIL3 Protein - H00004783-P01 from Novus Biologicals
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NFIL3-Antibody-N-term-Blocking-Peptide - BP16696a from Abgent, a WuXi AppTec company
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NFIL3 blocking peptide - GTX89990-PEP from GeneTex
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NFIL3 Immunizing peptide - orb16938 from Biorbyt
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NFIL3 Peptide - AC21-0086-P from Abcore
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NFIL3 - H00004783-P01-10 from Acris Antibodies
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NFIL3 - H00004783-P01-25 from Acris Antibodies
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NFIL3 Peptide - 45-965P from ProSci
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NFIL3 fusion protein - ag2380 from Proteintech Group
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NFIL3 Blocking Peptide - CBP4121 from Cohesion Biosciences
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E4BP4 (E65) Peptide - BS2076P from Bioworld Technology
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Recombinant Human Nuclear factor interleukin-3-regulated protein(NFIL3) - CSB-YP621967HU CSB-EP621967HU CSB-BP621967HU CSB-MP621967HU from Cusabio
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NFIL3, Peptide - MBS633898 from MyBioSource
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NFIL3, Peptide - MBS426385 from MyBioSource
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NFIL3 Blocking Peptide - abx162614 from Abbexa
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NFIL3 Peptide, Human - M34GP10339H from Creative Peptides
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Nuclear factor interleukin-3-regulated protein (NFIL3), Recombinant Protein - MBS1486469 from MyBioSource
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