| Gene Symbol |
Nalcn
|
| Entrez Gene |
338370
|
| Alt Symbol |
A530023G15Rik, AI849508, Vgcnl1
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
sodium leak channel, non-selective
|
| Other Description |
sodium leak channel non-selective protein|voltage gated channel like 1|voltage gated channel-like protein 1
|
| Swissprots |
Q8BYM2 Q8BXR5
|
| Accessions |
Q8BXR5 AK036122 AK039034 BAC30213 AK040761 AK043071 AK044431 BAC31915 AK143219 AK161382 CD802755 XM_011245093 XP_011243395 XM_011245094 XP_011243396 XM_011245095 XP_011243397 XM_011245096 XP_011243398 NM_177754 NM_177393 NP_796367
|
| Function |
Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival. {ECO:0000269|PubMed:17448995, ECO:0000269|PubMed:19092807}.
|
| Subcellular Location |
Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}.
|
| Tissue Specificity |
Widely expressed in the brain and spinal cord neurons. {ECO:0000269|PubMed:17448995}.
|