Gene Symbol | Nalcn |
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Entrez Gene | 338370 |
Alt Symbol | A530023G15Rik, AI849508, Vgcnl1 |
Species | Mouse |
Gene Type | protein-coding |
Description | sodium leak channel, non-selective |
Other Description | sodium leak channel non-selective protein|voltage gated channel like 1|voltage gated channel-like protein 1 |
Swissprots | Q8BYM2 Q8BXR5 |
Accessions | Q8BXR5 AK036122 AK039034 BAC30213 AK040761 AK043071 AK044431 BAC31915 AK143219 AK161382 CD802755 XM_011245093 XP_011243395 XM_011245094 XP_011243396 XM_011245095 XP_011243397 XM_011245096 XP_011243398 NM_177754 NM_177393 NP_796367 |
Function | Voltage-independent, cation-nonselective channel which is permeable to sodium, potassium and calcium ions. Responsible for the background sodium ion leak current in neurons and controls neuronal excitability. Activated either by neuropeptides substance P or neurotensin. Required for normal respiratory rhythm and neonatal survival. {ECO:0000269|PubMed:17448995, ECO:0000269|PubMed:19092807}. |
Subcellular Location | Membrane {ECO:0000305}; Multi-pass membrane protein {ECO:0000305}. |
Tissue Specificity | Widely expressed in the brain and spinal cord neurons. {ECO:0000269|PubMed:17448995}. |
NALCN CRISPR/Cas9 KO Plasmid (m) - sc-436118 from Santa Cruz Biotechnology
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NALCN HDR Plasmid (m) - sc-436118-HDR from Santa Cruz Biotechnology
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NALCN Double Nickase Plasmid (m) - sc-436118-NIC from Santa Cruz Biotechnology
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NALCN Double Nickase Plasmid (m2) - sc-436118-NIC-2 from Santa Cruz Biotechnology
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NALCN CRISPR Activation Plasmid (m) - sc-436118-ACT from Santa Cruz Biotechnology
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NALCN CRISPR Activation Plasmid (m2) - sc-436118-ACT-2 from Santa Cruz Biotechnology
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NALCN Lentiviral Activation Particles (m) - sc-436118-LAC from Santa Cruz Biotechnology
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NALCN Lentiviral Activation Particles (m2) - sc-436118-LAC-2 from Santa Cruz Biotechnology
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NALCN siRNA (m) - sc-149810 from Santa Cruz Biotechnology
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NALCN shRNA Plasmid (m) - sc-149810-SH from Santa Cruz Biotechnology
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NALCN shRNA (m) Lentiviral Particles - sc-149810-V from Santa Cruz Biotechnology
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MISSION® esiRNA - EMU073981 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN36183 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND36183 from Sigma-Aldrich
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NALCN siRNA (Mouse) - CRN4721 from Cohesion Biosciences
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shRNA set against Mouse NALCN (NM_177393.4) - SHH349132 from Creative biogene
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NALCN shRNA Plasmid (Mouse) - CHN4721 from Cohesion Biosciences
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NALCN miRNA 3'UTR clone - MiUTR1M-12680 from Creative biogene
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